| pubmed-article:1467954 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1467954 | lifeskim:mentions | umls-concept:C1708480 | lld:lifeskim |
| pubmed-article:1467954 | lifeskim:mentions | umls-concept:C1522565 | lld:lifeskim |
| pubmed-article:1467954 | lifeskim:mentions | umls-concept:C0008810 | lld:lifeskim |
| pubmed-article:1467954 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:1467954 | lifeskim:mentions | umls-concept:C0001962 | lld:lifeskim |
| pubmed-article:1467954 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:1467954 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1467954 | lifeskim:mentions | umls-concept:C1710706 | lld:lifeskim |
| pubmed-article:1467954 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1467954 | pubmed:dateCreated | 1993-1-26 | lld:pubmed |
| pubmed-article:1467954 | pubmed:abstractText | The neocortical ventricular zone is composed of a desynchronized population of proliferating cells. These cells give rise to neurons in the infragranular laminae of neocortex. The present study documents a diurnal rhythmicity of cell proliferation in the ventricular zone and examines the effects of ethanol on this biological clock. Pregnant rats were fed one of 3 diets. They were provided an ethanol-containing (6.7% v/v) liquid diet ad libitum between gestational day (G) 6 and G18, pair-fed an isocaloric liquid control diet, or fed chow and water. Throughout the experiments, the rats were fed either at 08.00 h (E.S.T) or at 17.00 h (lights on 06.00 to 18.00 h). Rats were given a single injection of bromodeoxyuridine (BrdU) on G17 at one point during a 24 h period (03.00, 06.00, 09.00 h, etc.). The fraction of ventricular cells that incorporated the BrdU was determined using quantitative immunohistochemical methods. Pair-fed control rats (fed at 08.00 or 17.00 h) consumed their food within 4 h of presentation. The ratio of cells passing through the S-phase of the cell cycle changed diurnally; the ratio was highest during the day (0.52 +/- 0.01 at 12.00 h) and lowest during the night (0.40 +/- 0.02 at 03.00 h). In contrast, the ethanol-fed rats grazed on their food throughout the dark cycle regardless of when the food was presented. The mean peak blood ethanol concentration was 142 +/- 13 mg/dl during the dark phase and less than 25 mg/dl during the light phase. Prenatal exposure to ethanol eliminates the fetal circadian rhythm in cell proliferation (mean labeling index of 0.45 +/- 0.03).(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:1467954 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1467954 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1467954 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1467954 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1467954 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1467954 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1467954 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1467954 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1467954 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1467954 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1467954 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:1467954 | pubmed:author | pubmed-author:MillerM WMW | lld:pubmed |
| pubmed-article:1467954 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1467954 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:1467954 | pubmed:volume | 595 | lld:pubmed |
| pubmed-article:1467954 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1467954 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1467954 | pubmed:pagination | 17-24 | lld:pubmed |
| pubmed-article:1467954 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1467954 | pubmed:meshHeading | pubmed-meshheading:1467954-... | lld:pubmed |
| pubmed-article:1467954 | pubmed:meshHeading | pubmed-meshheading:1467954-... | lld:pubmed |
| pubmed-article:1467954 | pubmed:meshHeading | pubmed-meshheading:1467954-... | lld:pubmed |
| pubmed-article:1467954 | pubmed:meshHeading | pubmed-meshheading:1467954-... | lld:pubmed |
| pubmed-article:1467954 | pubmed:meshHeading | pubmed-meshheading:1467954-... | lld:pubmed |
| pubmed-article:1467954 | pubmed:meshHeading | pubmed-meshheading:1467954-... | lld:pubmed |
| pubmed-article:1467954 | pubmed:meshHeading | pubmed-meshheading:1467954-... | lld:pubmed |
| pubmed-article:1467954 | pubmed:meshHeading | pubmed-meshheading:1467954-... | lld:pubmed |
| pubmed-article:1467954 | pubmed:meshHeading | pubmed-meshheading:1467954-... | lld:pubmed |
| pubmed-article:1467954 | pubmed:meshHeading | pubmed-meshheading:1467954-... | lld:pubmed |
| pubmed-article:1467954 | pubmed:meshHeading | pubmed-meshheading:1467954-... | lld:pubmed |
| pubmed-article:1467954 | pubmed:meshHeading | pubmed-meshheading:1467954-... | lld:pubmed |
| pubmed-article:1467954 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1467954 | pubmed:articleTitle | Circadian rhythm of cell proliferation in the telencephalic ventricular zone: effect of in utero exposure to ethanol. | lld:pubmed |
| pubmed-article:1467954 | pubmed:affiliation | Research Service, Veterans Affairs Medical Center, Iowa City, IA 52242. | lld:pubmed |
| pubmed-article:1467954 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1467954 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1467954 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1467954 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1467954 | lld:pubmed |
