Linked Life Data

14678035

Source:http://linkedlifedata.com/resource/pubmed/id/14678035

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pubmed-article:14678035pubmed:abstractTextThe prolonged survival of donor hematopoietic stem cells is crucial to the success of bone marrow transplantation. The anti-apoptotic gene Bcl-xL has been shown to promote survival of cells of the erythroid, myeloid and lymphoid lineages. To evaluate a potential therapeutic role for Bcl-xL, we used a retroviral vector to express Bcl-xL in donor cells used for murine bone marrow transplantation. We find that Bcl-xL expression in bone marrow cells facilitates hematopoietic reconstitution (as assessed by total cellularity) without altering cell differentiation. Most importantly, cells reconstituted with Bcl-xL are able to achieve high levels of donor chimerism even in non-ablative conditioning protocols in a syngeneic model of transplantation. Thus, expression of Bcl-xL by donor cells during bone marrow transplantation may provide a means to minimize host conditioning and toxicity while still achieving therapeutic degrees of mixed chimerism.lld:pubmed
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pubmed-article:14678035pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:14678035pubmed:articleTitleBcl-XL expression in stem cells facilitates engraftment and reduces the need for host conditioning during bone marrow transplantation.lld:pubmed
pubmed-article:14678035pubmed:affiliationDepartment of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.lld:pubmed
pubmed-article:14678035pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:14678035pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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