| pubmed-article:14677138 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14677138 | lifeskim:mentions | umls-concept:C1412481 | lld:lifeskim |
| pubmed-article:14677138 | lifeskim:mentions | umls-concept:C0011570 | lld:lifeskim |
| pubmed-article:14677138 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:14677138 | lifeskim:mentions | umls-concept:C0392334 | lld:lifeskim |
| pubmed-article:14677138 | lifeskim:mentions | umls-concept:C0392335 | lld:lifeskim |
| pubmed-article:14677138 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:14677138 | pubmed:dateCreated | 2003-12-16 | lld:pubmed |
| pubmed-article:14677138 | pubmed:abstractText | There is a recognized but poorly understood relationship between late-life depression (LLD) and progressive dementia. Both cognitive impairment co-occurring with LLD and a late age-of-onset of first lifetime depressive episode appear to be associated with subsequent progressive dementia. A history of major depression, especially when the first onset occurs in late-life, has been identified as a risk factor for Alzheimer's disease (AD). The major genetic risk factor for sporadic AD is carrying one or more apolipoprotein E4 (APOE4) alleles. We hypothesized that the association between LLD and dementia risk would be mediated by APOE4, specifically that APOE4 allele frequency would be associated with cognitive impairment and later age-of-depression-onset. We also predicted that APOE4 allele frequency would be increased among subjects with LLD. | lld:pubmed |
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| pubmed-article:14677138 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14677138 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14677138 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14677138 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14677138 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14677138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14677138 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14677138 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:14677138 | pubmed:issn | 0885-6230 | lld:pubmed |
| pubmed-article:14677138 | pubmed:author | pubmed-author:SweetRobert... | lld:pubmed |
| pubmed-article:14677138 | pubmed:author | pubmed-author:DeKoskySteven... | lld:pubmed |
| pubmed-article:14677138 | pubmed:author | pubmed-author:ReynoldsCharl... | lld:pubmed |
| pubmed-article:14677138 | pubmed:author | pubmed-author:PollockBruce... | lld:pubmed |
| pubmed-article:14677138 | pubmed:author | pubmed-author:MulsantBenoit... | lld:pubmed |
| pubmed-article:14677138 | pubmed:author | pubmed-author:BegleyAmy EAE | lld:pubmed |
| pubmed-article:14677138 | pubmed:author | pubmed-author:ButtersMeryl... | lld:pubmed |
| pubmed-article:14677138 | pubmed:author | pubmed-author:Ilyas... | lld:pubmed |
| pubmed-article:14677138 | pubmed:copyrightInfo | Copyright 2003 John Wiley & Sons, Ltd. | lld:pubmed |
| pubmed-article:14677138 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14677138 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:14677138 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14677138 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14677138 | pubmed:pagination | 1075-81 | lld:pubmed |
| pubmed-article:14677138 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:14677138 | pubmed:meshHeading | pubmed-meshheading:14677138... | lld:pubmed |
| pubmed-article:14677138 | pubmed:meshHeading | pubmed-meshheading:14677138... | lld:pubmed |
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| pubmed-article:14677138 | pubmed:meshHeading | pubmed-meshheading:14677138... | lld:pubmed |
| pubmed-article:14677138 | pubmed:meshHeading | pubmed-meshheading:14677138... | lld:pubmed |
| pubmed-article:14677138 | pubmed:meshHeading | pubmed-meshheading:14677138... | lld:pubmed |
| pubmed-article:14677138 | pubmed:meshHeading | pubmed-meshheading:14677138... | lld:pubmed |
| pubmed-article:14677138 | pubmed:meshHeading | pubmed-meshheading:14677138... | lld:pubmed |
| pubmed-article:14677138 | pubmed:meshHeading | pubmed-meshheading:14677138... | lld:pubmed |
| pubmed-article:14677138 | pubmed:meshHeading | pubmed-meshheading:14677138... | lld:pubmed |
| pubmed-article:14677138 | pubmed:meshHeading | pubmed-meshheading:14677138... | lld:pubmed |
| pubmed-article:14677138 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14677138 | pubmed:articleTitle | APOE is associated with age-of-onset, but not cognitive functioning, in late-life depression. | lld:pubmed |
| pubmed-article:14677138 | pubmed:affiliation | Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. buttersma@upmc.edu | lld:pubmed |
| pubmed-article:14677138 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14677138 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:348 | entrezgene:pubmed | pubmed-article:14677138 | lld:entrezgene |
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