| pubmed-article:14676632 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14676632 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:14676632 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:14676632 | lifeskim:mentions | umls-concept:C0242629 | lld:lifeskim |
| pubmed-article:14676632 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:14676632 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:14676632 | lifeskim:mentions | umls-concept:C0042196 | lld:lifeskim |
| pubmed-article:14676632 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
| pubmed-article:14676632 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:14676632 | lifeskim:mentions | umls-concept:C0750729 | lld:lifeskim |
| pubmed-article:14676632 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:14676632 | pubmed:dateCreated | 2003-12-16 | lld:pubmed |
| pubmed-article:14676632 | pubmed:abstractText | Successful immunotherapy with peptide vaccines depends on the in vivo generation of sufficient numbers of anti-tumor T cells with appropriate phenotypic and functional characteristics to mediate tumor destruction. Herein, we report the induction of high frequencies of circulating CD8+ T cells (4.8% to 38.1%) directed against the native gp100:209-217 peptide derived from the gp100 melanoma-melanocyte tumor antigen in five HLA-A*0201 patients at high risk of recurrence of melanoma after multiple courses of immunization with modified gp100:209-217(210M) peptide in IFA. Longitudinal peripheral blood mononuclear cell (PBMC) analysis revealed a phenotypic shift of native peptide-specific CD8+ T cells from an early effector to an effector memory (CD27- CD28- CD62L- CD45RO+) phenotype with repeated immunizations and functional maturation that correlated with gp100:209-217 peptide-specific T-cell precursor frequencies. Postimmunization PBMC exhibited direct ex vivo recognition of melanoma cell lines in ELISPOT analysis, showed lytic capability against peptide-pulsed target cells, and proliferated in response to native peptide stimulation. One year after final immunization, circulating vaccine-specific CD8+ T cells persisted in patients' PBMC with a maintained effector memory phenotype. The results herein demonstrate the efficacy of a multiple course peptide-immunization strategy for the generation of high frequencies of tumor antigen-specific T cells in vivo, and further show that continued peptide immunization results in the escalating generation of functionally mature, tumor-reactive effector memory CD8+ T lymphocytes. | lld:pubmed |
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| pubmed-article:14676632 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:14676632 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14676632 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14676632 | pubmed:issn | 1524-9557 | lld:pubmed |
| pubmed-article:14676632 | pubmed:author | pubmed-author:RosenbergStev... | lld:pubmed |
| pubmed-article:14676632 | pubmed:author | pubmed-author:PowellDaniel... | lld:pubmed |
| pubmed-article:14676632 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14676632 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:14676632 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14676632 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14676632 | pubmed:pagination | 36-47 | lld:pubmed |
| pubmed-article:14676632 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:14676632 | pubmed:articleTitle | Phenotypic and functional maturation of tumor antigen-reactive CD8+ T lymphocytes in patients undergoing multiple course peptide vaccination. | lld:pubmed |
| pubmed-article:14676632 | pubmed:affiliation | Surgery Branch, National Cancer Institutes of Health, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:14676632 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14676632 | pubmed:publicationType | Evaluation Studies | lld:pubmed |
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