| pubmed-article:14673141 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14673141 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:14673141 | lifeskim:mentions | umls-concept:C1417701 | lld:lifeskim |
| pubmed-article:14673141 | lifeskim:mentions | umls-concept:C0033554 | lld:lifeskim |
| pubmed-article:14673141 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:14673141 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:14673141 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:14673141 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:14673141 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:14673141 | pubmed:dateCreated | 2003-12-15 | lld:pubmed |
| pubmed-article:14673141 | pubmed:abstractText | Activated macrophages express high levels of Nrf2, a transcription factor that positively regulates the gene expression of antioxidant and detoxication enzymes. In this study, we examined how Nrf2 contributes to the anti-inflammatory process. As a model system of acute inflammation, we administered carrageenan to induce pleurisy and found that in Nrf2-deficient mice, tissue invasion by neutrophils persisted during inflammation and the recruitment of macrophages was delayed. Using an antibody against 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), it was observed that macrophages from pleural lavage accumulate 15d-PGJ(2). We show that in mouse peritoneal macrophages 15d-PGJ(2) can activate Nrf2 by forming adducts with Keap1, resulting in an Nrf2-dependent induction of heme oxygenase 1 and peroxiredoxin I (PrxI) gene expression. Administration of the cyclooxygenase 2 inhibitor NS-398 to mice with carrageenan-induced pleurisy caused persistence of neutrophil recruitment and, in macrophages, attenuated the 15d-PGJ(2) accumulation and PrxI expression. Administration of 15d-PGJ(2) into the pleural space of NS-398-treated wild-type mice largely counteracted both the decrease in PrxI and persistence of neutrophil recruitment. In contrast, these changes did not occur in the Nrf2-deficient mice. These results demonstrate that Nrf2 regulates the inflammation process downstream of 15d-PGJ(2) by orchestrating the recruitment of inflammatory cells and regulating the gene expression within those cells. | lld:pubmed |
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| pubmed-article:14673141 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14673141 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14673141 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14673141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14673141 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14673141 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14673141 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:14673141 | pubmed:author | pubmed-author:YamamotoMasay... | lld:pubmed |
| pubmed-article:14673141 | pubmed:author | pubmed-author:UchidaKojiK | lld:pubmed |
| pubmed-article:14673141 | pubmed:author | pubmed-author:ItohKenK | lld:pubmed |
| pubmed-article:14673141 | pubmed:author | pubmed-author:SekizawaKiyoh... | lld:pubmed |
| pubmed-article:14673141 | pubmed:author | pubmed-author:MochizukiMieM | lld:pubmed |
| pubmed-article:14673141 | pubmed:author | pubmed-author:ShibataTakahi... | lld:pubmed |
| pubmed-article:14673141 | pubmed:author | pubmed-author:IshiiYukioY | lld:pubmed |
| pubmed-article:14673141 | pubmed:author | pubmed-author:IshiiTetsuroT | lld:pubmed |
| pubmed-article:14673141 | pubmed:author | pubmed-author:KawamotoYoshi... | lld:pubmed |
| pubmed-article:14673141 | pubmed:author | pubmed-author:KellyVincentV | lld:pubmed |
| pubmed-article:14673141 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14673141 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:14673141 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14673141 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14673141 | pubmed:pagination | 36-45 | lld:pubmed |
| pubmed-article:14673141 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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