Linked Life Data

14671650

Source:http://linkedlifedata.com/resource/pubmed/id/14671650

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:14671650rdf:typepubmed:Citationlld:pubmed
pubmed-article:14671650lifeskim:mentionsumls-concept:C0684224lld:lifeskim
pubmed-article:14671650lifeskim:mentionsumls-concept:C1704387lld:lifeskim
pubmed-article:14671650lifeskim:mentionsumls-concept:C1522642lld:lifeskim
pubmed-article:14671650lifeskim:mentionsumls-concept:C0021027lld:lifeskim
pubmed-article:14671650lifeskim:mentionsumls-concept:C0441472lld:lifeskim
pubmed-article:14671650lifeskim:mentionsumls-concept:C1511790lld:lifeskim
pubmed-article:14671650lifeskim:mentionsumls-concept:C0032520lld:lifeskim
pubmed-article:14671650lifeskim:mentionsumls-concept:C0524889lld:lifeskim
pubmed-article:14671650lifeskim:mentionsumls-concept:C0678936lld:lifeskim
pubmed-article:14671650lifeskim:mentionsumls-concept:C0442711lld:lifeskim
pubmed-article:14671650lifeskim:mentionsumls-concept:C0038136lld:lifeskim
pubmed-article:14671650lifeskim:mentionsumls-concept:C1707689lld:lifeskim
pubmed-article:14671650lifeskim:mentionsumls-concept:C1571873lld:lifeskim
pubmed-article:14671650lifeskim:mentionsumls-concept:C0206415lld:lifeskim
pubmed-article:14671650pubmed:issue12lld:pubmed
pubmed-article:14671650pubmed:dateCreated2003-12-12lld:pubmed
pubmed-article:14671650pubmed:abstractTextIn a European BIOMED-2 collaborative study, multiplex PCR assays have successfully been developed and standardized for the detection of clonally rearranged immunoglobulin (Ig) and T-cell receptor (TCR) genes and the chromosome aberrations t(11;14) and t(14;18). This has resulted in 107 different primers in only 18 multiplex PCR tubes: three VH-JH, two DH-JH, two Ig kappa (IGK), one Ig lambda (IGL), three TCR beta (TCRB), two TCR gamma (TCRG), one TCR delta (TCRD), three BCL1-Ig heavy chain (IGH), and one BCL2-IGH. The PCR products of Ig/TCR genes can be analyzed for clonality assessment by heteroduplex analysis or GeneScanning. The detection rate of clonal rearrangements using the BIOMED-2 primer sets is unprecedentedly high. This is mainly based on the complementarity of the various BIOMED-2 tubes. In particular, combined application of IGH (VH-JH and DH-JH) and IGK tubes can detect virtually all clonal B-cell proliferations, even in B-cell malignancies with high levels of somatic mutations. The contribution of IGL gene rearrangements seems limited. Combined usage of the TCRB and TCRG tubes detects virtually all clonal T-cell populations, whereas the TCRD tube has added value in case of TCRgammadelta(+) T-cell proliferations. The BIOMED-2 multiplex tubes can now be used for diagnostic clonality studies as well as for the identification of PCR targets suitable for the detection of minimal residual disease.lld:pubmed
pubmed-article:14671650pubmed:languageenglld:pubmed
pubmed-article:14671650pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14671650pubmed:citationSubsetIMlld:pubmed
pubmed-article:14671650pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14671650pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14671650pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14671650pubmed:statusMEDLINElld:pubmed
pubmed-article:14671650pubmed:monthDeclld:pubmed
pubmed-article:14671650pubmed:issn0887-6924lld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:SmithJ LJLlld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:GonzálezDDlld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:GonzálezMMlld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:HummelMMlld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:MorganG JGJlld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:DroeseJJlld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:WhiteH EHElld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:LangerakA WAWlld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:ParreiraAAlld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:SchuuringEElld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:BastardCClld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:MacintyreE...lld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:SpaargarenMMlld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:LavenderF LFLlld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:KnebaMMlld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:BrüggemannMMlld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:DaviFFlld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:DelabesseEElld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:García-SanzRRlld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:van DongenJ...lld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:van...lld:pubmed
pubmed-article:14671650pubmed:authorpubmed-author:EvansP A SPAlld:pubmed
pubmed-article:14671650pubmed:issnTypePrintlld:pubmed
pubmed-article:14671650pubmed:volume17lld:pubmed
pubmed-article:14671650pubmed:ownerNLMlld:pubmed
pubmed-article:14671650pubmed:authorsCompleteYlld:pubmed
pubmed-article:14671650pubmed:pagination2257-317lld:pubmed
pubmed-article:14671650pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:14671650pubmed:meshHeadingpubmed-meshheading:14671650...lld:pubmed
pubmed-article:14671650pubmed:meshHeadingpubmed-meshheading:14671650...lld:pubmed
pubmed-article:14671650pubmed:meshHeadingpubmed-meshheading:14671650...lld:pubmed
pubmed-article:14671650pubmed:meshHeadingpubmed-meshheading:14671650...lld:pubmed
pubmed-article:14671650pubmed:meshHeadingpubmed-meshheading:14671650...lld:pubmed
pubmed-article:14671650pubmed:meshHeadingpubmed-meshheading:14671650...lld:pubmed
pubmed-article:14671650pubmed:meshHeadingpubmed-meshheading:14671650...lld:pubmed
pubmed-article:14671650pubmed:meshHeadingpubmed-meshheading:14671650...lld:pubmed
pubmed-article:14671650pubmed:meshHeadingpubmed-meshheading:14671650...lld:pubmed
pubmed-article:14671650pubmed:meshHeadingpubmed-meshheading:14671650...lld:pubmed
pubmed-article:14671650pubmed:meshHeadingpubmed-meshheading:14671650...lld:pubmed
pubmed-article:14671650pubmed:meshHeadingpubmed-meshheading:14671650...lld:pubmed
pubmed-article:14671650pubmed:meshHeadingpubmed-meshheading:14671650...lld:pubmed
pubmed-article:14671650pubmed:year2003lld:pubmed
pubmed-article:14671650pubmed:articleTitleDesign and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936.lld:pubmed
pubmed-article:14671650pubmed:affiliationDepartment of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. j.j.m.vandongen@erasmusmc.nllld:pubmed
pubmed-article:14671650pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:14671650pubmed:publicationTypeReviewlld:pubmed
pubmed-article:14671650pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:14671650pubmed:publicationTypeMulticenter Studylld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14671650lld:pubmed
More...