| pubmed-article:14667198 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14667198 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:14667198 | lifeskim:mentions | umls-concept:C0005955 | lld:lifeskim |
| pubmed-article:14667198 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:14667198 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:14667198 | lifeskim:mentions | umls-concept:C1155872 | lld:lifeskim |
| pubmed-article:14667198 | lifeskim:mentions | umls-concept:C1332710 | lld:lifeskim |
| pubmed-article:14667198 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:14667198 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:14667198 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:14667198 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:14667198 | pubmed:dateCreated | 2003-12-11 | lld:pubmed |
| pubmed-article:14667198 | pubmed:abstractText | To investigate the relationship between c-kit expression and cell cycle regulation by endogenous transforming growth factor-beta (TGF-beta) in human bone marrow hematopoietic progenitor cells, CD34+ CD38- c-kit(low/-) and CD34+ CD38- c-kit(high) populations were cultured in stem cell factor, thrombopoietin, interleukin-3 (IL-3), IL-6, granulocyte colony-stimulating factor, granulocyte/macrophage colony-stimulating factor and anti-TGF-beta, and analyzed for cell cycle status. Arrest in G0/G1 was most prominent in the precultured CD34+ CD38- c-kit(low/-) subset (95.62 +/- 4.15%). While postcultured CD34+ CD38- c-kit(high) cells initiated from CD34+ CD38- c-kit(high) cells entered cell cycle within 36 hr, postcultured CD34+ CD38- c-kit(low/-) cells initiated from CD34+ CD38- c-kit(low/-) cells remained dormant until 36 hr and entered cell cycle within 90 hr. Anti-TGF-beta increased the percentage of S/G2M phase postcultured CD34+ CD38- c-kit(high) cells (from 19.08 +/- 11.95 to 47.04 +/- 2.93%), but no significant change was observed in postcultured CD34+ CD38- c-kit(low/-) cells. These results suggest that endogenous TGF-beta plays an important role in the cell cycle arrest of c-kit(high) but not c-kit(low/-) cells in CD34+ CD38- cells, which proliferate without undergoing differentiation. The different regulatory mechanism of cell cycle entry of the CD34+ CD38- c-kit(high) and CD34+ CD38- c-kit(low/-) subsets might be the result of differences in their sensitivity to endogenous TGF-beta. | lld:pubmed |
| pubmed-article:14667198 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14667198 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14667198 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14667198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14667198 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14667198 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14667198 | pubmed:issn | 0902-4441 | lld:pubmed |
| pubmed-article:14667198 | pubmed:author | pubmed-author:TanizawaTakak... | lld:pubmed |
| pubmed-article:14667198 | pubmed:author | pubmed-author:MoritaNaokoN | lld:pubmed |
| pubmed-article:14667198 | pubmed:author | pubmed-author:YamamotoMasuj... | lld:pubmed |
| pubmed-article:14667198 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14667198 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:14667198 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14667198 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14667198 | pubmed:pagination | 351-8 | lld:pubmed |
| pubmed-article:14667198 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:14667198 | pubmed:meshHeading | pubmed-meshheading:14667198... | lld:pubmed |
| pubmed-article:14667198 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14667198 | pubmed:articleTitle | Correlation of c-kit expression and cell cycle regulation by transforming growth factor-beta in CD34+ CD38- human bone marrow cells. | lld:pubmed |
| pubmed-article:14667198 | pubmed:affiliation | Department of Pediatrics, Hyogo College of Medicine 1-1 Mukogawa-cho, Nishinomiya, Hyogo, Japan. mori-ped@hyo-med.ac.jp | lld:pubmed |
| pubmed-article:14667198 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14667198 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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