| pubmed-article:14665420 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14665420 | lifeskim:mentions | umls-concept:C0038454 | lld:lifeskim |
| pubmed-article:14665420 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:14665420 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:14665420 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:14665420 | lifeskim:mentions | umls-concept:C0085872 | lld:lifeskim |
| pubmed-article:14665420 | lifeskim:mentions | umls-concept:C1883709 | lld:lifeskim |
| pubmed-article:14665420 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14665420 | pubmed:dateCreated | 2003-12-10 | lld:pubmed |
| pubmed-article:14665420 | pubmed:abstractText | We investigated microvascular damage in areas with magnetic resonance imaging (MRI)-defined apparent diffusion coefficient reduction (ADC-R) in a rat model of thromboembolic occlusion of the middle cerebral artery. Rats received either intracarotid recombinant tissue plasminogen activator (rt-PA) or saline. Microvascular basal lamina damage was quantified by immunohistochemical staining of collagen type IV and by videoimaging analysis. ADC-R positive basal ganglia (cortical) areas showed a significant reduction of stained microvascular area by 15+/-6% (8+/-7%) and the microvascular density by 13+/-5% (8+/-6%) of that on the non-ischemic control side (P<0.001). There were no significant microvascular differences between rats given rt-PA or saline, or between those with or without angiographically proven recanalization. This study reports for the first time that microvascular basal lamina damage in experimental thromboembolic stroke is confined to regions with ADC-R in MRI. | lld:pubmed |
| pubmed-article:14665420 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14665420 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14665420 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14665420 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14665420 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14665420 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14665420 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:14665420 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:14665420 | pubmed:author | pubmed-author:RathN CNC | lld:pubmed |
| pubmed-article:14665420 | pubmed:author | pubmed-author:HamannGerhard... | lld:pubmed |
| pubmed-article:14665420 | pubmed:author | pubmed-author:BurggrafDorot... | lld:pubmed |
| pubmed-article:14665420 | pubmed:author | pubmed-author:BültemeierGun... | lld:pubmed |
| pubmed-article:14665420 | pubmed:author | pubmed-author:VoskoMilan... | lld:pubmed |
| pubmed-article:14665420 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14665420 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:14665420 | pubmed:volume | 353 | lld:pubmed |
| pubmed-article:14665420 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14665420 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14665420 | pubmed:pagination | 217-20 | lld:pubmed |
| pubmed-article:14665420 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:14665420 | pubmed:meshHeading | pubmed-meshheading:14665420... | lld:pubmed |
| pubmed-article:14665420 | pubmed:meshHeading | pubmed-meshheading:14665420... | lld:pubmed |
| pubmed-article:14665420 | pubmed:meshHeading | pubmed-meshheading:14665420... | lld:pubmed |
| pubmed-article:14665420 | pubmed:meshHeading | pubmed-meshheading:14665420... | lld:pubmed |
| pubmed-article:14665420 | pubmed:meshHeading | pubmed-meshheading:14665420... | lld:pubmed |
| pubmed-article:14665420 | pubmed:meshHeading | pubmed-meshheading:14665420... | lld:pubmed |
| pubmed-article:14665420 | pubmed:meshHeading | pubmed-meshheading:14665420... | lld:pubmed |
| pubmed-article:14665420 | pubmed:meshHeading | pubmed-meshheading:14665420... | lld:pubmed |
| pubmed-article:14665420 | pubmed:meshHeading | pubmed-meshheading:14665420... | lld:pubmed |
| pubmed-article:14665420 | pubmed:meshHeading | pubmed-meshheading:14665420... | lld:pubmed |
| pubmed-article:14665420 | pubmed:meshHeading | pubmed-meshheading:14665420... | lld:pubmed |
| pubmed-article:14665420 | pubmed:meshHeading | pubmed-meshheading:14665420... | lld:pubmed |
| pubmed-article:14665420 | pubmed:meshHeading | pubmed-meshheading:14665420... | lld:pubmed |
| pubmed-article:14665420 | pubmed:meshHeading | pubmed-meshheading:14665420... | lld:pubmed |
| pubmed-article:14665420 | pubmed:meshHeading | pubmed-meshheading:14665420... | lld:pubmed |
| pubmed-article:14665420 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14665420 | pubmed:articleTitle | Microvascular basal lamina damage in thromboembolic stroke in a rat model. | lld:pubmed |
| pubmed-article:14665420 | pubmed:affiliation | Department of Neurology, Ludwig-Maximilians University, Klinikum Grosshadern, Marchioninistrasse 15, D-81377 Munich, Germany. | lld:pubmed |
| pubmed-article:14665420 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14665420 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:14665420 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14665420 | lld:pubmed |
