| pubmed-article:14661054 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14661054 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:14661054 | lifeskim:mentions | umls-concept:C0137209 | lld:lifeskim |
| pubmed-article:14661054 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:14661054 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:14661054 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:14661054 | pubmed:dateCreated | 2004-1-29 | lld:pubmed |
| pubmed-article:14661054 | pubmed:abstractText | Beta-catenin is an essential element for the transcriptional activation of target genes in the Wnt signaling cascade and is also a cell adhesion molecule that couples with cadherins. Although plakoglobin (gamma-catenin), a closely related homologue of beta-catenin, is also known to be a cell adhesion molecule, its function as a transcriptional factor has not been revealed in detail. Using a human malignant mesothelioma cell line, NCI-H28, in which we have identified a homozygous deletion of the beta-catenin gene, we studied whether plakoglobin has a T-cell factor/lymphocyte enhancer factor (TCF/LEF) family-dependent transcriptional activity. Transfection with the wild-type plakoglobin expression vector induced accumulation of plakoglobin in the nucleus. Immunoprecipitation assay with cotransfection of plakoglobin and either TCF-4 or LEF-1 detected binding of plakoglobin to TCF-4 or LEF-1. Luciferase reporter assay demonstrated transcriptional activity of the wild-type plakoglobin when transfected with TCF/LEF, although plakoglobin showed less activity than beta-catenin. Exogenous plakoglobin was also shown to promote entrance of exogenous beta-catenin into the nuclei. Furthermore, small interfering RNA directed against plakoglobin suppressed expression of endogenous plakoglobin and its transcriptional activity, suggesting that endogenous plakoglobin has a weak transcriptional activity. These results suggest that plakoglobin can activate the Wnt signaling cascade directly without interaction of beta-catenin, and that plakoglobin has multiple functions as a transcriptional activator and a cell adhesion molecule like beta-catenin. | lld:pubmed |
| pubmed-article:14661054 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14661054 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14661054 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14661054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14661054 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14661054 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14661054 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:14661054 | pubmed:author | pubmed-author:GotoHidemiH | lld:pubmed |
| pubmed-article:14661054 | pubmed:author | pubmed-author:KusugamiKazuo... | lld:pubmed |
| pubmed-article:14661054 | pubmed:author | pubmed-author:TakahashiMasa... | lld:pubmed |
| pubmed-article:14661054 | pubmed:author | pubmed-author:MaedaOsamuO | lld:pubmed |
| pubmed-article:14661054 | pubmed:author | pubmed-author:ShimokataKaor... | lld:pubmed |
| pubmed-article:14661054 | pubmed:author | pubmed-author:KondoMasashiM | lld:pubmed |
| pubmed-article:14661054 | pubmed:author | pubmed-author:SekidoYoshita... | lld:pubmed |
| pubmed-article:14661054 | pubmed:author | pubmed-author:UsamiNoriyasu... | lld:pubmed |
| pubmed-article:14661054 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14661054 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:14661054 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:14661054 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14661054 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14661054 | pubmed:pagination | 964-72 | lld:pubmed |
| pubmed-article:14661054 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:14661054 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14661054 | pubmed:articleTitle | Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line. | lld:pubmed |
| pubmed-article:14661054 | pubmed:affiliation | Department of Internal Medicine, Nagoya University School of Medicine, Tsurumai-cho 65, Showa-ku, Nagoya 466-8560, Japan. | lld:pubmed |
| pubmed-article:14661054 | pubmed:publicationType | Journal Article | lld:pubmed |
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