| pubmed-article:14657208 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14657208 | lifeskim:mentions | umls-concept:C0006864 | lld:lifeskim |
| pubmed-article:14657208 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:14657208 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:14657208 | lifeskim:mentions | umls-concept:C1522564 | lld:lifeskim |
| pubmed-article:14657208 | lifeskim:mentions | umls-concept:C0282554 | lld:lifeskim |
| pubmed-article:14657208 | lifeskim:mentions | umls-concept:C0035126 | lld:lifeskim |
| pubmed-article:14657208 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:14657208 | lifeskim:mentions | umls-concept:C0208757 | lld:lifeskim |
| pubmed-article:14657208 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:14657208 | lifeskim:mentions | umls-concept:C1514758 | lld:lifeskim |
| pubmed-article:14657208 | lifeskim:mentions | umls-concept:C2612881 | lld:lifeskim |
| pubmed-article:14657208 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:14657208 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14657208 | pubmed:dateCreated | 2004-3-5 | lld:pubmed |
| pubmed-article:14657208 | pubmed:abstractText | In this study, we have assessed the activation of the cannabinoid CB2 receptor (CB2-R) in a model of mouse myocardial ischemia/reperfusion (I/R). The results show that treatment of animals with WIN55212-2, a CB1/CB2-R agonist, given 30 min before induction of I/R, significantly reduced the extent of infarct size (IS) in the area at risk, as measured 2.5 h later, with almost a 51% inhibition observed at the dose tested of 3.5 mg/kg intraperitoneally (i.p.). The protective effect of WIN55212-2 was almost abolished by the selective CB2-R antagonist AM630 (1 mg/kg i.p.) and not affected by the selective CB1-R antagonist AM251 (3 mg/kg i.p.). The CB2-R antagonist administered alone produced a slight but significant (P<0.05) increase in IS compared with vehicle alone. The protection afforded by WIN55212-2 was paralleled by lower values of myeloperoxidase activity and interleukin-1beta and of the CXC chemokine ligand 8 into the injured tissue. In conclusion, we demonstrate for the first time that exogenous and endogenous CB2-R activation reduces the leukocyte-dependent myocardial damage associated with an I/R procedure. | lld:pubmed |
| pubmed-article:14657208 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14657208 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14657208 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14657208 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14657208 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:14657208 | pubmed:issn | 0741-5400 | lld:pubmed |
| pubmed-article:14657208 | pubmed:author | pubmed-author:D'AmicoMichel... | lld:pubmed |
| pubmed-article:14657208 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:14657208 | pubmed:author | pubmed-author:RossiFrancesc... | lld:pubmed |
| pubmed-article:14657208 | pubmed:author | pubmed-author:RossiSettimio... | lld:pubmed |
| pubmed-article:14657208 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14657208 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:14657208 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14657208 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14657208 | pubmed:pagination | 453-9 | lld:pubmed |
| pubmed-article:14657208 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:14657208 | pubmed:meshHeading | pubmed-meshheading:14657208... | lld:pubmed |
| pubmed-article:14657208 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14657208 | pubmed:articleTitle | Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: involvement of cytokine/chemokines and PMN. | lld:pubmed |
| pubmed-article:14657208 | pubmed:affiliation | Department of Experimental Medicine, Section of Pharmacology L Donatelli, Second University of Naples, Italy. | lld:pubmed |
| pubmed-article:14657208 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14657208 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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