Linked Life Data

1465136

Source:http://linkedlifedata.com/resource/pubmed/id/1465136

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pubmed-article:1465136pubmed:abstractTextExon sequences present on separate RNA molecules can be joined by trans-splicing in trypanosomatids, Euglena, and in the nematode and trematode worms. Trans-splicing involves an interaction between a 5' splice site present in a spliced leader RNA and a 3' splice site located near the 5' end of pre-messenger RNAs. In vitro trans-splicing of artificial mammalian pre-mRNAs has been reported, but the efficiency of splicing appears to depend on sequence complementarity between the two substrates. There has been speculation that some natural pre-mRNAs can be trans-spliced in mammalian cells in vivo, but alternative interpretations have not been ruled out. Here we show that spliced leader RNAs can be accurately trans-spliced in mammalian cells in vivo and in vitro. Both nematode and mammalian 3' splice sites can function as acceptors for trans-splicing in vivo. These results reveal functional conservation in the splicing machinery between lower eukaryotes and mammals, and they directly demonstrate the potential for trans-splicing in mammalian cells.lld:pubmed
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pubmed-article:1465136pubmed:articleTitleSpliced leader RNAs from lower eukaryotes are trans-spliced in mammalian cells.lld:pubmed
pubmed-article:1465136pubmed:affiliationDepartment of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.lld:pubmed
pubmed-article:1465136pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1465136pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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