| pubmed-article:14640545 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14640545 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:14640545 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:14640545 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
| pubmed-article:14640545 | lifeskim:mentions | umls-concept:C0680730 | lld:lifeskim |
| pubmed-article:14640545 | lifeskim:mentions | umls-concept:C0005456 | lld:lifeskim |
| pubmed-article:14640545 | lifeskim:mentions | umls-concept:C0870071 | lld:lifeskim |
| pubmed-article:14640545 | lifeskim:mentions | umls-concept:C1148554 | lld:lifeskim |
| pubmed-article:14640545 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:14640545 | lifeskim:mentions | umls-concept:C0599740 | lld:lifeskim |
| pubmed-article:14640545 | pubmed:issue | 25 | lld:pubmed |
| pubmed-article:14640545 | pubmed:dateCreated | 2003-12-3 | lld:pubmed |
| pubmed-article:14640545 | pubmed:abstractText | On the basis of a set of 20 diverse 5-HT(7) receptor agonists, the pharmacophore for 5-HT(7) receptor agonism was determined. Additionally two CoMFA models were developed, based on different alignments of the agonists. Both models show good correlations between experimental and predictive pK(i) values and show a high degree of similarity. The CoMFA fields were subsequently used to map the agonist binding site of the model of the 5-HT(7) receptor. Important roles in ligand binding are attributed to Asp162 of TM3 (interaction with a protonated nitrogen), and Thr244 of TM5 (interaction with a substituent at an aromatic moiety). Amino acid residues of the aromatic cluster of TM6 are hypothesized to play an important role in ligand binding as pi-pi stacking moieties. Agonists missing a hydrogen-bond-accepting moiety, but possessing an aromatic substituent instead, seem to bind the receptor with high affinity as well by occupying a lipophilic pocket hosted by residues of TM5 and TM6. | lld:pubmed |
| pubmed-article:14640545 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14640545 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14640545 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14640545 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14640545 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14640545 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14640545 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14640545 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14640545 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14640545 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14640545 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:14640545 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:14640545 | pubmed:author | pubmed-author:WikströmHåkan... | lld:pubmed |
| pubmed-article:14640545 | pubmed:author | pubmed-author:VermeulenErik... | lld:pubmed |
| pubmed-article:14640545 | pubmed:author | pubmed-author:SchmidtAnne... | lld:pubmed |
| pubmed-article:14640545 | pubmed:author | pubmed-author:SprouseJeffre... | lld:pubmed |
| pubmed-article:14640545 | pubmed:author | pubmed-author:GrolCor JCJ | lld:pubmed |
| pubmed-article:14640545 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14640545 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:14640545 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:14640545 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14640545 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14640545 | pubmed:pagination | 5365-74 | lld:pubmed |
| pubmed-article:14640545 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:14640545 | pubmed:meshHeading | pubmed-meshheading:14640545... | lld:pubmed |
| pubmed-article:14640545 | pubmed:meshHeading | pubmed-meshheading:14640545... | lld:pubmed |
| pubmed-article:14640545 | pubmed:meshHeading | pubmed-meshheading:14640545... | lld:pubmed |
| pubmed-article:14640545 | pubmed:meshHeading | pubmed-meshheading:14640545... | lld:pubmed |
| pubmed-article:14640545 | pubmed:meshHeading | pubmed-meshheading:14640545... | lld:pubmed |
| pubmed-article:14640545 | pubmed:meshHeading | pubmed-meshheading:14640545... | lld:pubmed |
| pubmed-article:14640545 | pubmed:meshHeading | pubmed-meshheading:14640545... | lld:pubmed |
| pubmed-article:14640545 | pubmed:meshHeading | pubmed-meshheading:14640545... | lld:pubmed |
| pubmed-article:14640545 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14640545 | pubmed:articleTitle | Characterization of the 5-HT(7) receptor. Determination of the pharmacophore for 5-HT(7) receptor agonism and CoMFA-based modeling of the agonist binding site. | lld:pubmed |
| pubmed-article:14640545 | pubmed:affiliation | Department of Medicinal Chemistry, Center for Pharmacy, State University of Groningen, A Deusinglaan 1, NL-9713 AV Groningen, The Netherlands. e.s.vermeulen@farm.rug.nl | lld:pubmed |
| pubmed-article:14640545 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:14640545 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14640545 | lld:pubmed |
