| pubmed-article:14639604 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14639604 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:14639604 | lifeskim:mentions | umls-concept:C1709130 | lld:lifeskim |
| pubmed-article:14639604 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:14639604 | lifeskim:mentions | umls-concept:C0007102 | lld:lifeskim |
| pubmed-article:14639604 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:14639604 | lifeskim:mentions | umls-concept:C1622501 | lld:lifeskim |
| pubmed-article:14639604 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:14639604 | lifeskim:mentions | umls-concept:C0027108 | lld:lifeskim |
| pubmed-article:14639604 | lifeskim:mentions | umls-concept:C1522484 | lld:lifeskim |
| pubmed-article:14639604 | lifeskim:mentions | umls-concept:C0036525 | lld:lifeskim |
| pubmed-article:14639604 | lifeskim:mentions | umls-concept:C0812204 | lld:lifeskim |
| pubmed-article:14639604 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:14639604 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:14639604 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:14639604 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:14639604 | pubmed:dateCreated | 2003-11-25 | lld:pubmed |
| pubmed-article:14639604 | pubmed:abstractText | The nm23-H1 gene is known as a potential metastasis suppressor gene in various types of carcinomas. However, the role of nm23-H1 in colorectal carcinoma still remains controversial and the cellular mechanisms by which its protein may modulate the metastatic phenotype are not yet known. We transfected nm23-H1 cDNA into the human colon cancer cell line, HT-29, to test the effects and cellular biological mechanism of nm23 protein in colon cancer. We found that nm23-H1 strongly inhibited the liver metastasis of HT-29 cells in nude mice and inhibited the epidermal growth factor (EGF)-induced cell migration in vitro. Furthermore, we clarified the regulation of the myosin light chain (MLC) phosphorylation by nm23-H1, which has been demonstrated as having potential role in cell migration. | lld:pubmed |
| pubmed-article:14639604 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14639604 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14639604 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14639604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14639604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14639604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14639604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14639604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14639604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14639604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14639604 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14639604 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14639604 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:14639604 | pubmed:author | pubmed-author:ShimizuNobuyo... | lld:pubmed |
| pubmed-article:14639604 | pubmed:author | pubmed-author:TsukudaKazuno... | lld:pubmed |
| pubmed-article:14639604 | pubmed:author | pubmed-author:SuzukiEijiE | lld:pubmed |
| pubmed-article:14639604 | pubmed:author | pubmed-author:MurakamiMasak... | lld:pubmed |
| pubmed-article:14639604 | pubmed:author | pubmed-author:OtaTetsuyaT | lld:pubmed |
| pubmed-article:14639604 | pubmed:author | pubmed-author:DoiharaHiroyo... | lld:pubmed |
| pubmed-article:14639604 | pubmed:author | pubmed-author:MatsuokaKinya... | lld:pubmed |
| pubmed-article:14639604 | pubmed:author | pubmed-author:OkitaAtsushiA | lld:pubmed |
| pubmed-article:14639604 | pubmed:copyrightInfo | Copyright 2003 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:14639604 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14639604 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:14639604 | pubmed:volume | 108 | lld:pubmed |
| pubmed-article:14639604 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14639604 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14639604 | pubmed:pagination | 207-11 | lld:pubmed |
| pubmed-article:14639604 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:14639604 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14639604 | pubmed:articleTitle | nm23-H1 reduces in vitro cell migration and the liver metastatic potential of colon cancer cells by regulating myosin light chain phosphorylation. | lld:pubmed |
| pubmed-article:14639604 | pubmed:affiliation | Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan. | lld:pubmed |
| pubmed-article:14639604 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14639604 | pubmed:publicationType | In Vitro | lld:pubmed |
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