| pubmed-article:14638696 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14638696 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:14638696 | lifeskim:mentions | umls-concept:C1367449 | lld:lifeskim |
| pubmed-article:14638696 | lifeskim:mentions | umls-concept:C1335624 | lld:lifeskim |
| pubmed-article:14638696 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:14638696 | lifeskim:mentions | umls-concept:C1523116 | lld:lifeskim |
| pubmed-article:14638696 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:14638696 | pubmed:dateCreated | 2004-1-5 | lld:pubmed |
| pubmed-article:14638696 | pubmed:abstractText | Engagement of the T-cell receptor (TCR) initiates a signaling cascade that ultimately results in activation of the transcription factor NF-kappaB, which regulates many T-cell functions including proliferation, differentiation and cytokine production. Herein we demonstrate that Rip2, a caspase recruitment domain (CARD)-containing serine/threonine kinase, plays an important role in this cascade and is required for optimal TCR signaling and NF-kappaB activation. Following TCR engagement, Rip2 associated with Bcl10, a CARD-containing signaling component of the TCR-induced NF-kappaB pathway, and induced its phosphorylation. Rip2-deficient mice were defective in TCR-induced NF-kappaB activation, interleukin-2 production, and proliferation in vitro and exhibited defective T-cell-dependent responses in vivo. The defect in Rip2-/- T-cells correlated with a lack of TCR-induced Bcl10 phosphorylation. Furthermore, deficiency in Bcl10-dependent NF-kappaB activation could be rescued in Rip2-/- embryonic fibroblasts by exogenous wild-type Rip2 but not a kinase-dead mutant. Together these data define an important role for Rip2 in TCR-induced NF-kappaB activation and T-cell function and highlight the significance of post-translational modification of Bcl10 by Rip2 in T-cell signaling. | lld:pubmed |
| pubmed-article:14638696 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14638696 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14638696 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14638696 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14638696 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14638696 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14638696 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:14638696 | pubmed:author | pubmed-author:DixitVishva... | lld:pubmed |
| pubmed-article:14638696 | pubmed:author | pubmed-author:HurstStephenS | lld:pubmed |
| pubmed-article:14638696 | pubmed:author | pubmed-author:Ruefli-Brasse... | lld:pubmed |
| pubmed-article:14638696 | pubmed:author | pubmed-author:LeeWyne PWP | lld:pubmed |
| pubmed-article:14638696 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14638696 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:14638696 | pubmed:volume | 279 | lld:pubmed |
| pubmed-article:14638696 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14638696 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14638696 | pubmed:pagination | 1570-4 | lld:pubmed |
| pubmed-article:14638696 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:14638696 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14638696 | pubmed:articleTitle | Rip2 participates in Bcl10 signaling and T-cell receptor-mediated NF-kappaB activation. | lld:pubmed |
| pubmed-article:14638696 | pubmed:affiliation | Department of Molecular Oncology, Genentech, Inc., South San Francisco, California 94080, USA. | lld:pubmed |
| pubmed-article:14638696 | pubmed:publicationType | Journal Article | lld:pubmed |
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