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pubmed-article:14635183pubmed:abstractTextThere has been great progress in the design of vectors for cancer gene therapy. However, it has been difficult to translate success in the laboratory into clinical practice. A major hurdle in understanding these failures has been the relative difficulty in monitoring repeatedly and non-invasively the biodistribution, gene expression and replication of these viral vector systems. With the advent of molecular imaging technology, this deficiency is being rapidly rectified. A number of reporter genes have been used to monitor gene expression. In this review, we discuss the role of the sodium iodide symporter (NIS) as a reporter and therapeutic gene for cancer gene therapy when combined with various radioactive isotopes.lld:pubmed
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pubmed-article:14635183pubmed:copyrightInfoCopyright 2003 Wiley-Liss, Inc.lld:pubmed
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pubmed-article:14635183pubmed:pagination1079-86lld:pubmed
pubmed-article:14635183pubmed:dateRevised2006-4-21lld:pubmed
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pubmed-article:14635183pubmed:year2003lld:pubmed
pubmed-article:14635183pubmed:articleTitleIn vivo imaging and tumor therapy with the sodium iodide symporter.lld:pubmed
pubmed-article:14635183pubmed:affiliationMolecular Medicine Program, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, Minnesota 55905, USA.lld:pubmed
pubmed-article:14635183pubmed:publicationTypeJournal Articlelld:pubmed
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