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| pubmed-article:14635047 | lifeskim:mentions | umls-concept:C1333336 | lld:lifeskim |
| pubmed-article:14635047 | lifeskim:mentions | umls-concept:C0020835 | lld:lifeskim |
| pubmed-article:14635047 | lifeskim:mentions | umls-concept:C0021017 | lld:lifeskim |
| pubmed-article:14635047 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:14635047 | lifeskim:mentions | umls-concept:C0919432 | lld:lifeskim |
| pubmed-article:14635047 | lifeskim:mentions | umls-concept:C1419772 | lld:lifeskim |
| pubmed-article:14635047 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:14635047 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:14635047 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:14635047 | pubmed:dateCreated | 2003-11-24 | lld:pubmed |
| pubmed-article:14635047 | pubmed:abstractText | We have shown previously that Smad3 and Smad4 mediate TGF-beta1-induced IgA expression. In the present study, we examined the involvement of Runx3 in this process. Overexpression of Runx3 in mice increased germ-line alpha (GLalpha) transcription, and transcription was further augmented when B lymphoma and LPS-activated murine spleen cells were co-transfected with Smad3/4. Overexpression of Runx3 and Smad3/4 increased IgA secretion by both cell types in response to TGF-beta1. p300, which has histone acetyltransferase activity, further augmented TGF-beta1-induced GLalpha transcription promoted by Smad3/4 and Runx3. These observations were confirmed by examining the influence of Smad3/4, Runx3 and p300 on the expression of endogenous GLalpha and post-switch alpha transcripts.E1A, an inhibitor of p300, blocked both GLalpha promoter activity and the enhancement of endogenous GLalpha transcription by Smad3/4 and Runx3. We conclude that p300 cooperates with Smad3/4 and Runx3 in stimulating TGF-beta1-induced GLalpha transcription and subsequent IgA isotype expression, while E1A inhibits these cooperative effects. | lld:pubmed |
| pubmed-article:14635047 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:14635047 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14635047 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14635047 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:14635047 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:14635047 | pubmed:author | pubmed-author:KimByung-Chul... | lld:pubmed |
| pubmed-article:14635047 | pubmed:author | pubmed-author:KimPyeung-Hye... | lld:pubmed |
| pubmed-article:14635047 | pubmed:author | pubmed-author:ParkSeok-RaeS... | lld:pubmed |
| pubmed-article:14635047 | pubmed:author | pubmed-author:LeeEun-Kyoung... | lld:pubmed |
| pubmed-article:14635047 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14635047 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:14635047 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14635047 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14635047 | pubmed:pagination | 3386-92 | lld:pubmed |
| pubmed-article:14635047 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:14635047 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14635047 | pubmed:articleTitle | p300 cooperates with Smad3/4 and Runx3 in TGFbeta1-induced IgA isotype expression. | lld:pubmed |
| pubmed-article:14635047 | pubmed:affiliation | Department of Microbiology, College of Natural Sciences, Kangwon National University, Chunchon, S. Korea. | lld:pubmed |
| pubmed-article:14635047 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14635047 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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