| pubmed-article:1463467 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1463467 | lifeskim:mentions | umls-concept:C0005528 | lld:lifeskim |
| pubmed-article:1463467 | lifeskim:mentions | umls-concept:C0023828 | lld:lifeskim |
| pubmed-article:1463467 | lifeskim:mentions | umls-concept:C0017742 | lld:lifeskim |
| pubmed-article:1463467 | lifeskim:mentions | umls-concept:C0028027 | lld:lifeskim |
| pubmed-article:1463467 | pubmed:dateCreated | 1993-1-8 | lld:pubmed |
| pubmed-article:1463467 | pubmed:abstractText | A kinetic study of the uptake of nicotinamide by reconstituted liposomes containing the human erythrocyte glucose transporter, compared with that of D-glucose, demonstrated that the Km and Vmax. values were almost the same for each compound, and that the uptake of D-glucose was competitively inhibited by nicotinamide. At 20 mM concentration, 2-deoxy-D-glucose, 3-O-methyl-D-glucose and 4,6-O-ethylidene-D-glucose all caused 50% inhibition of nicotinamide uptake, but L-glucose and nicotinic acid were not inhibitory. Similar results were obtained for the uptake of D-glucose. Cytochalasin B binding to the liposomes was inhibited in a dose-dependent manner by either nicotinamide or D-glucose. Antibody for glucose transporter detected in band 4.5 by SDS/PAGE inhibited the uptake of D-glucose and nicotinamide. A possible uptake of nicotinamide by nucleoside transporter was excluded. In human erythrocytes, cytochalasin B binding was inhibited dose-dependently by either nicotinamide or D-glucose, and cytochalasin B depressed the uptake of both nicotinamide and 2-deoxy-D-glucose. These findings were well reproduced in the reconstituted liposomes. The very close similarities between uptake of nicotinamide and D-glucose suggest that the glucose transporter plays a direct role in transport of nicotinamide, which is structurally quite different from monosaccharides, and thus that the transporter is probably multifunctional. | lld:pubmed |
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| pubmed-article:1463467 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1463467 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1463467 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1463467 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1463467 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1463467 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:1463467 | pubmed:author | pubmed-author:NishidaMM | lld:pubmed |
| pubmed-article:1463467 | pubmed:author | pubmed-author:YoshimuraYY | lld:pubmed |
| pubmed-article:1463467 | pubmed:author | pubmed-author:KawadaJJ | lld:pubmed |
| pubmed-article:1463467 | pubmed:author | pubmed-author:SofueMM | lld:pubmed |
| pubmed-article:1463467 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1463467 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1463467 | pubmed:volume | 288 ( Pt 2) | lld:pubmed |
| pubmed-article:1463467 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1463467 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1463467 | pubmed:pagination | 669-74 | lld:pubmed |
| pubmed-article:1463467 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1463467 | pubmed:meshHeading | pubmed-meshheading:1463467-... | lld:pubmed |
| pubmed-article:1463467 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1463467 | pubmed:articleTitle | Possible multifunction of glucose transporter. Transport of nicotinamide by reconstituted liposomes. | lld:pubmed |
| pubmed-article:1463467 | pubmed:affiliation | Faculty of Pharmaceutical Sciences, University of Tokushima, Japan. | lld:pubmed |
| pubmed-article:1463467 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1463467 | pubmed:publicationType | In Vitro | lld:pubmed |
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