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pubmed-article:14633961pubmed:abstractTextHydrophobic bile acids contribute to hepatocellular injury in cholestasis and rapidly induce apoptosis in vitro; however, unlike Fas agonists, cholestasis does not cause extensive hepatocyte apoptosis. As antioxidants provide protection against bile acid induced liver injury, our premise was that bilirubin, a free radical scavenger with increased plasma levels in the presence of liver disease, could protect hepatocytes against bile acid induced apoptosis.lld:pubmed
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pubmed-article:14633961pubmed:articleTitleBilirubin inhibits bile acid induced apoptosis in rat hepatocytes.lld:pubmed
pubmed-article:14633961pubmed:affiliationClinica Medica 1, University of Padova, Italy.lld:pubmed
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