| pubmed-article:14633670 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14633670 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:14633670 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:14633670 | lifeskim:mentions | umls-concept:C0015780 | lld:lifeskim |
| pubmed-article:14633670 | lifeskim:mentions | umls-concept:C1510707 | lld:lifeskim |
| pubmed-article:14633670 | lifeskim:mentions | umls-concept:C0025684 | lld:lifeskim |
| pubmed-article:14633670 | lifeskim:mentions | umls-concept:C1326912 | lld:lifeskim |
| pubmed-article:14633670 | lifeskim:mentions | umls-concept:C1413868 | lld:lifeskim |
| pubmed-article:14633670 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:14633670 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:14633670 | lifeskim:mentions | umls-concept:C1550147 | lld:lifeskim |
| pubmed-article:14633670 | lifeskim:mentions | umls-concept:C0047964 | lld:lifeskim |
| pubmed-article:14633670 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:14633670 | pubmed:dateCreated | 2003-11-24 | lld:pubmed |
| pubmed-article:14633670 | pubmed:abstractText | Human CYP2A6 has been recognized as being involved in the mutagenic activation of promutagens such as the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Methoxsalen (8-methoxypsoralen) was reported to inhibit CYP2A6. In the present study, the inhibitory effects of methoxsalen on NNK-induced lung tumorigenesis in female A/J mice were examined. Female A/J mice were treated with methoxsalen at doses of 50 or 12.5 mg/kg body weight, given by stomach tube, daily for 3 days. One h after the final treatment, NNK was injected i.p. at a dose of 2 mg/mouse. The experiments were terminated 16 weeks after the first methoxsalen treatment, and lung adenomas were analyzed. Pretreatment of methoxsalen significantly reduced tumor incidence from 93.8% to 16.7% (50 mg/kg) and 20.0% (12.5 mg/kg), and tumor multiplicity from 5.97 to 0.23 (50 mg/kg) and 0.25 (12.5 mg/kg) tumors/mouse. These results clearly demonstrated that methoxsalen, a potent human CYP2A6 inhibitor, is a strong chemopreventive agent against NNK-induction of lung tumorigenesis. | lld:pubmed |
| pubmed-article:14633670 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14633670 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14633670 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14633670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14633670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14633670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14633670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14633670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14633670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14633670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14633670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14633670 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14633670 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14633670 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:14633670 | pubmed:author | pubmed-author:KamatakiTetsu... | lld:pubmed |
| pubmed-article:14633670 | pubmed:author | pubmed-author:MaetaHajimeH | lld:pubmed |
| pubmed-article:14633670 | pubmed:author | pubmed-author:YamazakiHiros... | lld:pubmed |
| pubmed-article:14633670 | pubmed:author | pubmed-author:ImaidaKatsumi... | lld:pubmed |
| pubmed-article:14633670 | pubmed:author | pubmed-author:SaooKousukeK | lld:pubmed |
| pubmed-article:14633670 | pubmed:author | pubmed-author:TakeuchiHijir... | lld:pubmed |
| pubmed-article:14633670 | pubmed:author | pubmed-author:YokohiraMasan... | lld:pubmed |
| pubmed-article:14633670 | pubmed:author | pubmed-author:IkedaMicoM | lld:pubmed |
| pubmed-article:14633670 | pubmed:author | pubmed-author:MiyazakiMasaf... | lld:pubmed |
| pubmed-article:14633670 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14633670 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:14633670 | pubmed:volume | 63 | lld:pubmed |
| pubmed-article:14633670 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14633670 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14633670 | pubmed:pagination | 7581-3 | lld:pubmed |
| pubmed-article:14633670 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:14633670 | pubmed:meshHeading | pubmed-meshheading:14633670... | lld:pubmed |
| pubmed-article:14633670 | pubmed:meshHeading | pubmed-meshheading:14633670... | lld:pubmed |
| pubmed-article:14633670 | pubmed:meshHeading | pubmed-meshheading:14633670... | lld:pubmed |
| pubmed-article:14633670 | pubmed:meshHeading | pubmed-meshheading:14633670... | lld:pubmed |
| pubmed-article:14633670 | pubmed:meshHeading | pubmed-meshheading:14633670... | lld:pubmed |
| pubmed-article:14633670 | pubmed:meshHeading | pubmed-meshheading:14633670... | lld:pubmed |
| pubmed-article:14633670 | pubmed:meshHeading | pubmed-meshheading:14633670... | lld:pubmed |
| pubmed-article:14633670 | pubmed:meshHeading | pubmed-meshheading:14633670... | lld:pubmed |
| pubmed-article:14633670 | pubmed:meshHeading | pubmed-meshheading:14633670... | lld:pubmed |
| pubmed-article:14633670 | pubmed:meshHeading | pubmed-meshheading:14633670... | lld:pubmed |
| pubmed-article:14633670 | pubmed:meshHeading | pubmed-meshheading:14633670... | lld:pubmed |
| pubmed-article:14633670 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14633670 | pubmed:articleTitle | Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice. | lld:pubmed |
| pubmed-article:14633670 | pubmed:affiliation | Onco-Pathology, Department of Pathology and Host-Defense, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan. | lld:pubmed |
| pubmed-article:14633670 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14633670 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14633670 | lld:pubmed |
