| pubmed-article:14633630 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14633630 | lifeskim:mentions | umls-concept:C0033164 | lld:lifeskim |
| pubmed-article:14633630 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:14633630 | lifeskim:mentions | umls-concept:C0008109 | lld:lifeskim |
| pubmed-article:14633630 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:14633630 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:14633630 | lifeskim:mentions | umls-concept:C1517676 | lld:lifeskim |
| pubmed-article:14633630 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:14633630 | pubmed:dateCreated | 2003-11-24 | lld:pubmed |
| pubmed-article:14633630 | pubmed:abstractText | Mice to which human prions efficiently transmit in short incubation periods are valuable not only as research tools of human prions but also as reliable diagnostic tools. We recently produced a line of knock-in mouse expressing a unique human-mouse chimeric PrP (Ki-ChM mouse), which has mouse-specific residues practically only at the C-terminal part after posttranslational modification, and here we attempted transmission of various human prions to assess the susceptibility profile of the mouse. Susceptibility varied considerably depending on prions inoculated: highly susceptible to MM1 and MV1 types of sporadic Creutzfeldt-Jakob disease (CJD), developing disease within approximately 150 days, familial CJD with M232R mutation, and dura graft-associated CJD (dCJD) without amyloid plaque; less susceptible to MM2-type sporadic CJD and variant CJD, with some mice lacking any sign of transmission; and totally resistant to VV2 type sporadic CJD and dCJD with amyloid plaque. The rather short incubation time achieved by Ki-ChM mice suggests new approaches to produce mice that develop prion disease with very short incubation periods. We compared the characteristic susceptibility profile of Ki-ChM with those of other precedent transgenic mice and discussed, including the prospects in developing genetically engineered mice susceptible to human prions. | lld:pubmed |
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| pubmed-article:14633630 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14633630 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14633630 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:14633630 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14633630 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:14633630 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:14633630 | pubmed:author | pubmed-author:IronsideJames... | lld:pubmed |
| pubmed-article:14633630 | pubmed:author | pubmed-author:KitamotoTetsu... | lld:pubmed |
| pubmed-article:14633630 | pubmed:author | pubmed-author:MohriShirouS | lld:pubmed |
| pubmed-article:14633630 | pubmed:author | pubmed-author:MuramotoTamak... | lld:pubmed |
| pubmed-article:14633630 | pubmed:author | pubmed-author:TaguchiYuzuru... | lld:pubmed |
| pubmed-article:14633630 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14633630 | pubmed:volume | 163 | lld:pubmed |
| pubmed-article:14633630 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14633630 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14633630 | pubmed:pagination | 2585-93 | lld:pubmed |
| pubmed-article:14633630 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:14633630 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14633630 | pubmed:articleTitle | Humanized knock-in mice expressing chimeric prion protein showed varied susceptibility to different human prions. | lld:pubmed |
| pubmed-article:14633630 | pubmed:affiliation | Department of Neurological Science, Tohoku University Graduate School of Medicine, Sendai, Japan. | lld:pubmed |
| pubmed-article:14633630 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14633630 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:19122 | entrezgene:pubmed | pubmed-article:14633630 | lld:entrezgene |
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