| pubmed-article:14632785 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14632785 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:14632785 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:14632785 | lifeskim:mentions | umls-concept:C0220806 | lld:lifeskim |
| pubmed-article:14632785 | lifeskim:mentions | umls-concept:C0441833 | lld:lifeskim |
| pubmed-article:14632785 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:14632785 | lifeskim:mentions | umls-concept:C1325847 | lld:lifeskim |
| pubmed-article:14632785 | lifeskim:mentions | umls-concept:C1999270 | lld:lifeskim |
| pubmed-article:14632785 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:14632785 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:14632785 | pubmed:dateCreated | 2003-11-24 | lld:pubmed |
| pubmed-article:14632785 | pubmed:abstractText | Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) effectively kills tumour cells but not normal cells. We investigated TRAIL sensitivity and the TRAIL-induced apoptosis signalling pathway in a panel of B-lymphocytic leukaemia cell lines. Depending upon TRAIL sensitivity, leukaemia cells could be divided into three groups: highly sensitive, moderately sensitive and resistant. TRAIL receptor-2 (DR5) plays an important role in transducing apoptosis signals. DR5 was internalized into the cytoplasm where it recruited FAS-associated death domain protein (FADD) under TRAIL stimulation in both sensitive and resistant cells. However, the active form of caspase-8 was recruited to FADD and only sensitive cells showed increased caspase-8 activity upon TRAIL stimulation. The caspase-8 specific inhibitor, Z-IETD, impaired caspase-8 activation and completely abrogated TRAIL-induced apoptosis. These results suggest that TRAIL resistance in B-lymphocytic leukaemia cells is due to negative regulation at the level of caspase-8 activation and that caspase-8 activation is an indispensable process in TRAIL-induced apoptosis. However, FADD-like interleukin-1 beta-converting enzyme inhibitory protein (c-FLIPL) was similarly expressed and down-regulated after TRAIL stimulation in both sensitive and resistant cells. Interestingly, in some cell lines, TRAIL sensitivity and caspase-8 activity was enhanced or restored with the treatment of cycloheximide (CHX). In addition, X-linked inhibitor of apoptosis (XIAP) levels decreased significantly and rapidly following treatment with CHX. Down-regulation of XIAP may be responsible for enhancement or restoration of TRAIL sensitivity after CHX treatment in B-lymphocytic leukaemia cells. | lld:pubmed |
| pubmed-article:14632785 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14632785 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14632785 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14632785 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:14632785 | pubmed:issn | 0007-1048 | lld:pubmed |
| pubmed-article:14632785 | pubmed:author | pubmed-author:HoM JMJ | lld:pubmed |
| pubmed-article:14632785 | pubmed:author | pubmed-author:KangJianJ | lld:pubmed |
| pubmed-article:14632785 | pubmed:author | pubmed-author:TanakaShigeki... | lld:pubmed |
| pubmed-article:14632785 | pubmed:author | pubmed-author:AzumaEiichiE | lld:pubmed |
| pubmed-article:14632785 | pubmed:author | pubmed-author:KomadaYoshihi... | lld:pubmed |
| pubmed-article:14632785 | pubmed:author | pubmed-author:ToyodaHidemiH | lld:pubmed |
| pubmed-article:14632785 | pubmed:author | pubmed-author:KisengeRodric... | lld:pubmed |
| pubmed-article:14632785 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14632785 | pubmed:volume | 123 | lld:pubmed |
| pubmed-article:14632785 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14632785 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14632785 | pubmed:pagination | 921-32 | lld:pubmed |
| pubmed-article:14632785 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:14632785 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14632785 | pubmed:articleTitle | Chemical sensitization and regulation of TRAIL-induced apoptosis in a panel of B-lymphocytic leukaemia cell lines. | lld:pubmed |
| pubmed-article:14632785 | pubmed:affiliation | Department of Pediatrics, Mie University School of Medicine, Tsu, Mie, Japan. | lld:pubmed |
| pubmed-article:14632785 | pubmed:publicationType | Journal Article | lld:pubmed |
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