| pubmed-article:14630943 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14630943 | lifeskim:mentions | umls-concept:C1413160 | lld:lifeskim |
| pubmed-article:14630943 | lifeskim:mentions | umls-concept:C0040357 | lld:lifeskim |
| pubmed-article:14630943 | lifeskim:mentions | umls-concept:C0450429 | lld:lifeskim |
| pubmed-article:14630943 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
| pubmed-article:14630943 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:14630943 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
| pubmed-article:14630943 | lifeskim:mentions | umls-concept:C1704241 | lld:lifeskim |
| pubmed-article:14630943 | lifeskim:mentions | umls-concept:C1101096 | lld:lifeskim |
| pubmed-article:14630943 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:14630943 | pubmed:dateCreated | 2003-11-21 | lld:pubmed |
| pubmed-article:14630943 | pubmed:abstractText | Heterochromatin proteins are thought to play key roles in chromatin structure and gene regulation, yet very few genes have been identified that are regulated by these proteins. We performed large-scale mapping and analysis of in vivo target loci of the proteins HP1, HP1c, and Su(var)3-9 in Drosophila Kc cells, which are of embryonic origin. For each protein, we identified approximately 100-200 target genes among >6000 probed loci. We found that HP1 and Su(var)3-9 bind together to transposable elements and genes that are predominantly pericentric. In addition, Su(var)3-9 binds without HP1 to a distinct set of nonpericentric genes. On chromosome 4, HP1 binds to many genes, mostly independent of Su(var)3-9. The binding pattern of HP1c is largely different from those of HP1 and Su(var)3-9. Target genes of HP1 and Su(var)3-9 show lower expression levels in Kc cells than do nontarget genes, but not if they are located in pericentric regions. Strikingly, in pericentric regions, target genes of Su(var)3-9 and HP1 are predominantly embryo-specific genes, whereas on the chromosome arms Su(var)3-9 is preferentially associated with a set of male-specific genes. These results demonstrate that, depending on chromosomal location, the HP1 and Su(var)3-9 proteins form different complexes that associate with specific sets of developmentally coexpressed genes. | lld:pubmed |
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| pubmed-article:14630943 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14630943 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14630943 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14630943 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14630943 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14630943 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:14630943 | pubmed:author | pubmed-author:DelrowJeffrey... | lld:pubmed |
| pubmed-article:14630943 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:14630943 | pubmed:author | pubmed-author:HenikoffSteve... | lld:pubmed |
| pubmed-article:14630943 | pubmed:author | pubmed-author:BussemakerHar... | lld:pubmed |
| pubmed-article:14630943 | pubmed:author | pubmed-author:SmothersJames... | lld:pubmed |
| pubmed-article:14630943 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:14630943 | pubmed:author | pubmed-author:GreilFraukeF | lld:pubmed |
| pubmed-article:14630943 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:14630943 | pubmed:author | pubmed-author:de WitElzoE | lld:pubmed |
| pubmed-article:14630943 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14630943 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:14630943 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:14630943 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14630943 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14630943 | pubmed:pagination | 2825-38 | lld:pubmed |
| pubmed-article:14630943 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:14630943 | pubmed:meshHeading | pubmed-meshheading:14630943... | lld:pubmed |
| pubmed-article:14630943 | pubmed:meshHeading | pubmed-meshheading:14630943... | lld:pubmed |
| pubmed-article:14630943 | pubmed:meshHeading | pubmed-meshheading:14630943... | lld:pubmed |
| pubmed-article:14630943 | pubmed:meshHeading | pubmed-meshheading:14630943... | lld:pubmed |
| pubmed-article:14630943 | pubmed:meshHeading | pubmed-meshheading:14630943... | lld:pubmed |
| pubmed-article:14630943 | pubmed:meshHeading | pubmed-meshheading:14630943... | lld:pubmed |
| pubmed-article:14630943 | pubmed:meshHeading | pubmed-meshheading:14630943... | lld:pubmed |
| pubmed-article:14630943 | pubmed:meshHeading | pubmed-meshheading:14630943... | lld:pubmed |
| pubmed-article:14630943 | pubmed:meshHeading | pubmed-meshheading:14630943... | lld:pubmed |
| pubmed-article:14630943 | pubmed:meshHeading | pubmed-meshheading:14630943... | lld:pubmed |
| pubmed-article:14630943 | pubmed:meshHeading | pubmed-meshheading:14630943... | lld:pubmed |
| pubmed-article:14630943 | pubmed:meshHeading | pubmed-meshheading:14630943... | lld:pubmed |
| pubmed-article:14630943 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14630943 | pubmed:articleTitle | Distinct HP1 and Su(var)3-9 complexes bind to sets of developmentally coexpressed genes depending on chromosomal location. | lld:pubmed |
