| pubmed-article:14630806 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14630806 | lifeskim:mentions | umls-concept:C0682458 | lld:lifeskim |
| pubmed-article:14630806 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:14630806 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:14630806 | lifeskim:mentions | umls-concept:C0243127 | lld:lifeskim |
| pubmed-article:14630806 | lifeskim:mentions | umls-concept:C1547239 | lld:lifeskim |
| pubmed-article:14630806 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:14630806 | lifeskim:mentions | umls-concept:C0443331 | lld:lifeskim |
| pubmed-article:14630806 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:14630806 | pubmed:dateCreated | 2004-3-4 | lld:pubmed |
| pubmed-article:14630806 | pubmed:abstractText | HIV-1 subverts antigen processing in dendritic cells (DCs) resulting in viral uptake, infection, and transfer to T cells. Although DCs bound monomeric gp120 and HIV-1 similarly, virus rarely colocalized with endolysosomal markers, unlike gp120, suggesting HIV-1 alters endolysosomal trafficking. Virus within DC intracellular compartments rapidly moved to DC-CD4+ lymphocyte synapses when introduced to CD4+ lymphocyte cultures. Although viral harboring and transfer from nonlysosomal compartments was transient, given DC-associated virus protein, nucleic acids, and infectious HIV-1 transfer to CD4+, lymphocytes decayed within 24 hours. However a second long-term transfer phase was apparent in immature DCs after 48 hours as a zidovudine-sensitive rise in proviral DNA. Therefore, DCs transfer HIV-1 to CD4+ lymphocytes in 2 distinct phases. Immature and mature DCs first divert virus from the endolysosomal pathway to the DC-T-cell synapse. Secondly, the later transfer phase from immature DCs is through de novo HIV-1 production. Thus, the controversy of DCs being infected or not infected for the mechanics of viral transfer to CD4+ lymphocytes can be addressed as a function of time. | lld:pubmed |
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| pubmed-article:14630806 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14630806 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14630806 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:14630806 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14630806 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:14630806 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:14630806 | pubmed:author | pubmed-author:RomaniNikolau... | lld:pubmed |
| pubmed-article:14630806 | pubmed:author | pubmed-author:FrankInesI | lld:pubmed |
| pubmed-article:14630806 | pubmed:author | pubmed-author:LifsonJeffrey... | lld:pubmed |
| pubmed-article:14630806 | pubmed:author | pubmed-author:PopeMelissaM | lld:pubmed |
| pubmed-article:14630806 | pubmed:author | pubmed-author:StösselHellaH | lld:pubmed |
| pubmed-article:14630806 | pubmed:author | pubmed-author:WilkinsonJohn... | lld:pubmed |
| pubmed-article:14630806 | pubmed:author | pubmed-author:CunninghamAnt... | lld:pubmed |
| pubmed-article:14630806 | pubmed:author | pubmed-author:Miranda-Sakse... | lld:pubmed |
| pubmed-article:14630806 | pubmed:author | pubmed-author:CameronPaul... | lld:pubmed |
| pubmed-article:14630806 | pubmed:author | pubmed-author:DableJoanneJ | lld:pubmed |
| pubmed-article:14630806 | pubmed:author | pubmed-author:PiatakMichael... | lld:pubmed |
| pubmed-article:14630806 | pubmed:author | pubmed-author:TurvilleStuar... | lld:pubmed |
| pubmed-article:14630806 | pubmed:author | pubmed-author:SantosJohn... | lld:pubmed |
| pubmed-article:14630806 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14630806 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:14630806 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:14630806 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14630806 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14630806 | pubmed:pagination | 2170-9 | lld:pubmed |
| pubmed-article:14630806 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:14630806 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14630806 | pubmed:articleTitle | Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells. | lld:pubmed |
| pubmed-article:14630806 | pubmed:affiliation | Centre for Virus Research, Westmead Millennium Institute, Sydney, Australia. | lld:pubmed |
| pubmed-article:14630806 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14630806 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14630806 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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