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pubmed-article:14630373pubmed:dateCreated2003-11-21lld:pubmed
pubmed-article:14630373pubmed:abstractTextA simple and sensitive HPLC method for the determination of gatifloxacin concentrations in human serum and urine was developed and validated. Serum proteins were removed by ultrafiltration through a filtering device after adding a displacing agent. Urine samples were diluted with mobile phase prior to injection. Separation was achieved with a C18 reverse-phase column and gatifloxacin concentrations were determined using ultraviolet detection. The quantitation limits of the assay were 100 ng/ml in serum and 1.0 microg/ml in urine. The assay method was successfully applied to a pharmacokinetic study of gatifloxacin in healthy volunteers.lld:pubmed
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pubmed-article:14630373pubmed:authorpubmed-author:SowinskiKevin...lld:pubmed
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pubmed-article:14630373pubmed:pagination167-73lld:pubmed
pubmed-article:14630373pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:14630373pubmed:year2003lld:pubmed
pubmed-article:14630373pubmed:articleTitleDetermination of gatifloxacin in human serum and urine by high-performance liquid chromatography with ultraviolet detection.lld:pubmed
pubmed-article:14630373pubmed:affiliationDepartment of Pharmacy Practice, School of Pharmacy and Pharmacal Sciences, Purdue University, W7555 Myers Building, 1001 West 10th Street, Indianapolis, IN 46202-2879, USA.lld:pubmed
pubmed-article:14630373pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:14630373pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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