Linked Life Data

14630083

Source:http://linkedlifedata.com/resource/pubmed/id/14630083

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:14630083rdf:typepubmed:Citationlld:pubmed
pubmed-article:14630083lifeskim:mentionsumls-concept:C0020094lld:lifeskim
pubmed-article:14630083lifeskim:mentionsumls-concept:C0086418lld:lifeskim
pubmed-article:14630083lifeskim:mentionsumls-concept:C1335960lld:lifeskim
pubmed-article:14630083lifeskim:mentionsumls-concept:C0229664lld:lifeskim
pubmed-article:14630083lifeskim:mentionsumls-concept:C0007601lld:lifeskim
pubmed-article:14630083lifeskim:mentionsumls-concept:C1510411lld:lifeskim
pubmed-article:14630083lifeskim:mentionsumls-concept:C0037083lld:lifeskim
pubmed-article:14630083lifeskim:mentionsumls-concept:C0013081lld:lifeskim
pubmed-article:14630083lifeskim:mentionsumls-concept:C0041904lld:lifeskim
pubmed-article:14630083lifeskim:mentionsumls-concept:C0205160lld:lifeskim
pubmed-article:14630083lifeskim:mentionsumls-concept:C0805732lld:lifeskim
pubmed-article:14630083lifeskim:mentionsumls-concept:C1332714lld:lifeskim
pubmed-article:14630083lifeskim:mentionsumls-concept:C0162493lld:lifeskim
pubmed-article:14630083lifeskim:mentionsumls-concept:C1366753lld:lifeskim
pubmed-article:14630083lifeskim:mentionsumls-concept:C1335283lld:lifeskim
pubmed-article:14630083lifeskim:mentionsumls-concept:C1710082lld:lifeskim
pubmed-article:14630083lifeskim:mentionsumls-concept:C1150611lld:lifeskim
pubmed-article:14630083lifeskim:mentionsumls-concept:C0182953lld:lifeskim
pubmed-article:14630083lifeskim:mentionsumls-concept:C0205548lld:lifeskim
pubmed-article:14630083lifeskim:mentionsumls-concept:C1548425lld:lifeskim
pubmed-article:14630083pubmed:issue1lld:pubmed
pubmed-article:14630083pubmed:dateCreated2003-11-21lld:pubmed
pubmed-article:14630083pubmed:abstractTextAdult T-cell leukemia (ATL) is an aggressive malignancy that is associated with human T-cell lymphotropic virus I (HTLV-I) infection. HTLV-I transformed T-cell lines and fresh ATL cells are characterized by constitutive activation of the interleukin-2 receptor (IL-2R) signaling pathway however, the mechanism(s) responsible for constitutive IL-2R activation are unknown. To further examine the cause of this signaling pathway deregulation, we measured mRNA and protein expression levels by real-time PCR and Western blots, respectively, of four negative regulators of the IL-2R signaling pathway including src homology 2 (SH2)-containing phosphatase (SHP1), cytokine-inducible (CIS) SH2-containing protein, suppressor of cytokine signaling-1 (SOCS1) and protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) in six HTLV-1 negative and seven HTLV-1 positive T-cell leukemia lines. The activation status of the JAK/STAT pathway was also examined. SHP1 mRNA and protein expression levels were selectively down regulated in all HTLV-1-infected transformed cell lines, while CIS, SOCS1, and PIAS3 protein expression were markedly but variably upregulated and the cells showed evidence of constitutive STAT3 activation. In acutely HTLV-1 infected primary CD4+ T-cells there was a gradual loss of SHP1 expression over 10 weeks in culture which correlated with progression from immortalization to transformation and loss of IL-2 dependence for growth. Two transformed cell lines that were established following HTLV-1 infection showed loss of SHP1 expression and overexpression of CIS, SOCS1, PIAS3. However, this overexpression was not adequate to block constitutive activation of the JAK/STAT pathway. Thus, multiple levels of IL-2 receptor signal deregulation are found in HTLV-1 transformed cells, which may be a result of early loss of SHP1 expression.lld:pubmed
pubmed-article:14630083pubmed:languageenglld:pubmed
pubmed-article:14630083pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:citationSubsetIMlld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630083pubmed:statusMEDLINElld:pubmed
pubmed-article:14630083pubmed:monthJanlld:pubmed
pubmed-article:14630083pubmed:issn0145-2126lld:pubmed
pubmed-article:14630083pubmed:authorpubmed-author:ZhangDongshen...lld:pubmed
pubmed-article:14630083pubmed:authorpubmed-author:ZhouChanghong...lld:pubmed
pubmed-article:14630083pubmed:authorpubmed-author:MarascoWayne...lld:pubmed
pubmed-article:14630083pubmed:authorpubmed-author:ChengJihuaJlld:pubmed
pubmed-article:14630083pubmed:issnTypePrintlld:pubmed
pubmed-article:14630083pubmed:volume28lld:pubmed
pubmed-article:14630083pubmed:ownerNLMlld:pubmed
pubmed-article:14630083pubmed:authorsCompleteYlld:pubmed
pubmed-article:14630083pubmed:pagination71-82lld:pubmed
pubmed-article:14630083pubmed:dateRevised2009-11-19lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:meshHeadingpubmed-meshheading:14630083...lld:pubmed
pubmed-article:14630083pubmed:year2004lld:pubmed
pubmed-article:14630083pubmed:articleTitleDown-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-cells.lld:pubmed
pubmed-article:14630083pubmed:affiliationDepartment of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.lld:pubmed
pubmed-article:14630083pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:14630083pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:8651entrezgene:pubmedpubmed-article:14630083lld:entrezgene
entrez-gene:1154entrezgene:pubmedpubmed-article:14630083lld:entrezgene
entrez-gene:5777entrezgene:pubmedpubmed-article:14630083lld:entrezgene
entrez-gene:10401entrezgene:pubmedpubmed-article:14630083lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:14630083lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:14630083lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:14630083lld:entrezgene
lhgdn:association:960lhgdn:found_inpubmed-article:14630083lld:lhgdn
lhgdn:association:12104lhgdn:found_inpubmed-article:14630083lld:lhgdn
lhgdn:association:29237lhgdn:found_inpubmed-article:14630083lld:lhgdn
lhgdn:association:61248lhgdn:found_inpubmed-article:14630083lld:lhgdn
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14630083lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14630083lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14630083lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14630083lld:pubmed
More...