Linked Life Data

14622120

Source:http://linkedlifedata.com/resource/pubmed/id/14622120

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pubmed-article:14622120pubmed:abstractTextAspartic acid (Asp) undergoes l-isomer-selective efflux transport across the blood-brain barrier (BBB). This transport system appears to play an important role in regulating l- and d-Asp levels in the brain. The purpose of this study was to identify the responsible transporters and elucidate the mechanism for l-isomer-selective Asp transport at the BBB. The l-isomer-selective uptake of Asp by conditionally immortalized mouse brain capillary endothelial cells used as an in vitro model of the BBB took place in an Na+- and pH-dependent manner. This process was inhibited by system ASC substrates such as l-alanine and l-serine, suggesting that system ASC transporters, ASCT1 and ASCT2, are involved in the l-isomer selective transport. Indeed, l-Asp uptake by oocytes injected with either ASCT1 or ASCT2 cRNA took place in a similar manner to that in cultured BBB cells, whereas no significant d-Asp uptake occurred. Although both ASCT1 and ASCT2 mRNA were expressed in the cultured BBB cells, the expression of ASCT2 mRNA was 6.7-fold greater than that of ASCT1. Moreover, immunohistochemical analysis suggests that ASCT2 is localized at the abluminal side of the mouse BBB. These results suggest that ASCT2 plays a key role in l-isomer-selective Asp efflux transport at the BBB.lld:pubmed
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pubmed-article:14622120pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:14622120pubmed:articleTitleThe l-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood-brain barrier.lld:pubmed
pubmed-article:14622120pubmed:affiliationDepartment of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences New Industry Creation Hatchery Center, Tohoku University, Sendai, Japan. terasaki@mail.pharm.tohoku.ac.jplld:pubmed
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pubmed-article:14622120pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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