| pubmed-article:14616780 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14616780 | lifeskim:mentions | umls-concept:C0009319 | lld:lifeskim |
| pubmed-article:14616780 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:14616780 | lifeskim:mentions | umls-concept:C0012476 | lld:lifeskim |
| pubmed-article:14616780 | lifeskim:mentions | umls-concept:C0028953 | lld:lifeskim |
| pubmed-article:14616780 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:14616780 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:14616780 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:14616780 | pubmed:dateCreated | 2003-11-17 | lld:pubmed |
| pubmed-article:14616780 | pubmed:abstractText | Intestinal inflammation in inflammatory bowel disease (IBD) and experimental models of colitis is characterized by a dysregulated intestinal immune response with elevated levels of Th1 cytokines. The luminal flora has been implicated as a major factor contributing to the initiation and perpetuation of inflammation in experimental colitis by mechanisms not known. Bacterial DNA contains unmethylated cytosin-guanosin dinucleotides (CpG) which strongly activate Th1-mediated immune responses. To test whether these CpG-motifs modulate intestinal inflammation we treated mice with dextran sulphate sodium (DSS)-induced colitis with CpG-containing oligodeoxynucleotides (CpG-ODN). CpG-ODN given after the onset of DSS colitis aggravated the disease, as indicated by a significantly increased loss of body weight and a 30% increase of the histological score. Further, we found a severe increase of proinflammatory cytokines (interleukin (IL)-6: 40-fold; interferon (IFN)-gamma: 11-fold). In a pretreatment setting CpG-ODN reduced weight loss significantly and reduced intestinal inflammation by 45%. Colonic IFN-gamma and IL-6 mRNA levels were reduced by 75%, and IL-10 was elevated by 400% compared to controls. The prophylactic CpG-effect was not imitated by IL-12 because IL-12 pretreatment was not protective. In time-course experiments, CpG-ODN pretreatment over 5 days resulted in a tolerance effect concerning its IFN-gamma-inducing quality, and during the following days of colitis induction IL-10 secretion from mesenterial lymph node cells was elevated compared to controls. Therefore, the prophylactic effect of CpG-ODN might be explained by its tolerizing effect and/or the increased ability for IL-10 production during the consecutive intestinal inflammation. | lld:pubmed |
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| pubmed-article:14616780 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14616780 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14616780 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14616780 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14616780 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14616780 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:14616780 | pubmed:author | pubmed-author:FalkWW | lld:pubmed |
| pubmed-article:14616780 | pubmed:author | pubmed-author:SchölmerichJJ | lld:pubmed |
| pubmed-article:14616780 | pubmed:author | pubmed-author:ObermeierFF | lld:pubmed |
| pubmed-article:14616780 | pubmed:author | pubmed-author:GrunwaldNN | lld:pubmed |
| pubmed-article:14616780 | pubmed:author | pubmed-author:HerfarthHH | lld:pubmed |
| pubmed-article:14616780 | pubmed:author | pubmed-author:StrauchU GUG | lld:pubmed |
| pubmed-article:14616780 | pubmed:author | pubmed-author:DungerNN | lld:pubmed |
| pubmed-article:14616780 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14616780 | pubmed:volume | 134 | lld:pubmed |
| pubmed-article:14616780 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14616780 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14616780 | pubmed:pagination | 217-24 | lld:pubmed |
| pubmed-article:14616780 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:14616780 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14616780 | pubmed:articleTitle | Contrasting activity of cytosin-guanosin dinucleotide oligonucleotides in mice with experimental colitis. | lld:pubmed |
| pubmed-article:14616780 | pubmed:affiliation | Department of Internal Medicine I, University of Regensburg, Regensburg, Germany. Florian.Obermeier@klinik.uni-regensburg.de | lld:pubmed |
| pubmed-article:14616780 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14616780 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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