| pubmed-article:14610284 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14610284 | lifeskim:mentions | umls-concept:C0042216 | lld:lifeskim |
| pubmed-article:14610284 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:14610284 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:14610284 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:14610284 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:14610284 | pubmed:dateCreated | 2003-12-3 | lld:pubmed |
| pubmed-article:14610284 | pubmed:abstractText | To circumvent apoptotic death, many viruses encode Bcl-2 homologous proteins that function at the mitochondria. Vaccinia virus, the prototypic member of the Poxviridae family, does not encode a Bcl-2 homolog but inhibits the mitochondrial arm of the apoptotic cascade by an unknown mechanism. We now report that F1L, a previously unidentified protein in vaccinia virus, is responsible for the inhibition of apoptosis. Cells infected with vaccinia virus are resistant to staurosporine-mediated cleavage of poly(ADP-ribose) polymerase, caspases 3 and 9, and release of cytochrome c. In contrast, a vaccinia virus deletion mutant, VV811, was unable to inhibit apoptosis; however, the antiapoptotic function was restored by expression of the F1L ORF, which is absent in VV811. Although F1L displays no homology to members of the Bcl-2 family, it localizes to the mitochondria through a C-terminal hydrophobic domain. We show that expression of F1L interferes with apoptosis by inhibiting the loss of the inner mitochondrial membrane potential and the release of cytochrome c. | lld:pubmed |
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| pubmed-article:14610284 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14610284 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14610284 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14610284 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14610284 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14610284 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:14610284 | pubmed:author | pubmed-author:BarryMicheleM | lld:pubmed |
| pubmed-article:14610284 | pubmed:author | pubmed-author:WasilenkoShaw... | lld:pubmed |
| pubmed-article:14610284 | pubmed:author | pubmed-author:StewartTara... | lld:pubmed |
| pubmed-article:14610284 | pubmed:author | pubmed-author:MeyersAdrienn... | lld:pubmed |
| pubmed-article:14610284 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14610284 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:14610284 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:14610284 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14610284 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14610284 | pubmed:pagination | 14345-50 | lld:pubmed |
| pubmed-article:14610284 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:14610284 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14610284 | pubmed:articleTitle | Vaccinia virus encodes a previously uncharacterized mitochondrial-associated inhibitor of apoptosis. | lld:pubmed |
| pubmed-article:14610284 | pubmed:affiliation | Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada T6G 2S2. | lld:pubmed |
| pubmed-article:14610284 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14610284 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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