| pubmed-article:14607277 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14607277 | lifeskim:mentions | umls-concept:C1530899 | lld:lifeskim |
| pubmed-article:14607277 | lifeskim:mentions | umls-concept:C0271510 | lld:lifeskim |
| pubmed-article:14607277 | lifeskim:mentions | umls-concept:C0205160 | lld:lifeskim |
| pubmed-article:14607277 | lifeskim:mentions | umls-concept:C0812385 | lld:lifeskim |
| pubmed-article:14607277 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:14607277 | lifeskim:mentions | umls-concept:C1414184 | lld:lifeskim |
| pubmed-article:14607277 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:14607277 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:14607277 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:14607277 | pubmed:dateCreated | 2003-11-10 | lld:pubmed |
| pubmed-article:14607277 | pubmed:abstractText | The low-affinity receptor for IgG, FcgammaRIIb, negatively regulates B cell antigen receptor (BCR)-mediated proliferative signalling. FcgammaRIIb has been reported to mediate this inhibition by uncoupling the BCR from the RasMAPkinase pathway. We now show that FcgammaRIIb-mediated negative feedback inhibition also correlates with induction of an Erk-associated phosphatase activity that reflects the rapid association of Erk and the MAPkinase phosphatase, Pac-1, and dephosphorylation and inactivation of ErkMAPkinase. This mechanism of abrogating ongoing ErkMAPkinase signalling therefore provides a rationale for rapid immune-complex-mediated feedback inhibition of active antigen-driven B cell responses. In addition, FcgammaRIIb signalling also induces the recruitment and activation of the 3'-inositol phosphatase, PTEN, which by antagonising PI 3kinase activity and inhibiting BCR-coupling to the anti-apoptotic kinase, Akt, provides an additional mechanism for FcgammaRIIb-mediated negative regulation of BCR-coupling to ErkMAPkinase, cell survival and proliferation. | lld:pubmed |
| pubmed-article:14607277 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14607277 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14607277 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14607277 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14607277 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14607277 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14607277 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14607277 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14607277 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14607277 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14607277 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14607277 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14607277 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14607277 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14607277 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14607277 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14607277 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14607277 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14607277 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14607277 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14607277 | pubmed:issn | 0898-6568 | lld:pubmed |
| pubmed-article:14607277 | pubmed:author | pubmed-author:BlairDerekD | lld:pubmed |
| pubmed-article:14607277 | pubmed:author | pubmed-author:ReidSteven... | lld:pubmed |
| pubmed-article:14607277 | pubmed:author | pubmed-author:HarnettMargar... | lld:pubmed |
| pubmed-article:14607277 | pubmed:author | pubmed-author:BrownKirsty... | lld:pubmed |
| pubmed-article:14607277 | pubmed:author | pubmed-author:NicholsonEmma... | lld:pubmed |
| pubmed-article:14607277 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14607277 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:14607277 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14607277 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14607277 | pubmed:pagination | 71-80 | lld:pubmed |
| pubmed-article:14607277 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:14607277 | pubmed:meshHeading | pubmed-meshheading:14607277... | lld:pubmed |
| pubmed-article:14607277 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14607277 | pubmed:articleTitle | FcgammaRIIb-mediated negative regulation of BCR signalling is associated with the recruitment of the MAPkinase-phosphatase, Pac-1, and the 3'-inositol phosphatase, PTEN. | lld:pubmed |
| pubmed-article:14607277 | pubmed:affiliation | Division of Immunology, Infection and Inflammation, University of Glasgow, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, Scotland, UK. | lld:pubmed |
| pubmed-article:14607277 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14607277 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14607277 | lld:pubmed |
