| pubmed-article:14600419 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14600419 | lifeskim:mentions | umls-concept:C0034417 | lld:lifeskim |
| pubmed-article:14600419 | lifeskim:mentions | umls-concept:C0025663 | lld:lifeskim |
| pubmed-article:14600419 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:14600419 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:14600419 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:14600419 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:14600419 | lifeskim:mentions | umls-concept:C0542301 | lld:lifeskim |
| pubmed-article:14600419 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:14600419 | lifeskim:mentions | umls-concept:C0205463 | lld:lifeskim |
| pubmed-article:14600419 | lifeskim:mentions | umls-concept:C0037633 | lld:lifeskim |
| pubmed-article:14600419 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:14600419 | pubmed:dateCreated | 2003-11-5 | lld:pubmed |
| pubmed-article:14600419 | pubmed:abstractText | The purpose of the present study was to examine the effect of quinine on intracellular Ca2+ ([Ca2+]i) levels in cultured neuro-2a cells, and to investigate the possibility of using [Ca2+]i levels to predict the bitterness of quinine solutions. [Ca2+]i levels in neuro-2a cells increased following stimulation by quinine in a concentration-related manner. There was a good linear correlationship between the quinine-induced increase in [Ca2+]i levels increase and the bitterness scores of the quinine solutions as assessed in human gustatory sensation tests (r2=0.918). The quinine-induced increase in [Ca2+]i levels was inhibited by thapsigargin (an inhibitor of the Ca2+ pump into intracellular stores), U73122 (an inhibitor of phospholipase C) and omega-conotoxin (an N-type Ca2+-channel blocker), but not by nifedipine (an L-type Ca2+-channel blocker). | lld:pubmed |
| pubmed-article:14600419 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14600419 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14600419 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14600419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14600419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14600419 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14600419 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14600419 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14600419 | pubmed:issn | 0918-6158 | lld:pubmed |
| pubmed-article:14600419 | pubmed:author | pubmed-author:TanakaNaokoN | lld:pubmed |
| pubmed-article:14600419 | pubmed:author | pubmed-author:ShinozukaKazu... | lld:pubmed |
| pubmed-article:14600419 | pubmed:author | pubmed-author:MatsuyamaKenj... | lld:pubmed |
| pubmed-article:14600419 | pubmed:author | pubmed-author:UchidaTakahir... | lld:pubmed |
| pubmed-article:14600419 | pubmed:author | pubmed-author:NakamuraTomok... | lld:pubmed |
| pubmed-article:14600419 | pubmed:author | pubmed-author:AkiyoshiTakes... | lld:pubmed |
| pubmed-article:14600419 | pubmed:author | pubmed-author:Kashiwayanagi... | lld:pubmed |
| pubmed-article:14600419 | pubmed:author | pubmed-author:MatznoSumioS | lld:pubmed |
| pubmed-article:14600419 | pubmed:author | pubmed-author:NakabayashiTo... | lld:pubmed |
| pubmed-article:14600419 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14600419 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:14600419 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14600419 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14600419 | pubmed:pagination | 1637-40 | lld:pubmed |
| pubmed-article:14600419 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:14600419 | pubmed:meshHeading | pubmed-meshheading:14600419... | lld:pubmed |
| pubmed-article:14600419 | pubmed:meshHeading | pubmed-meshheading:14600419... | lld:pubmed |
| pubmed-article:14600419 | pubmed:meshHeading | pubmed-meshheading:14600419... | lld:pubmed |
| pubmed-article:14600419 | pubmed:meshHeading | pubmed-meshheading:14600419... | lld:pubmed |
| pubmed-article:14600419 | pubmed:meshHeading | pubmed-meshheading:14600419... | lld:pubmed |
| pubmed-article:14600419 | pubmed:meshHeading | pubmed-meshheading:14600419... | lld:pubmed |
| pubmed-article:14600419 | pubmed:meshHeading | pubmed-meshheading:14600419... | lld:pubmed |
| pubmed-article:14600419 | pubmed:meshHeading | pubmed-meshheading:14600419... | lld:pubmed |
| pubmed-article:14600419 | pubmed:meshHeading | pubmed-meshheading:14600419... | lld:pubmed |
| pubmed-article:14600419 | pubmed:meshHeading | pubmed-meshheading:14600419... | lld:pubmed |
| pubmed-article:14600419 | pubmed:meshHeading | pubmed-meshheading:14600419... | lld:pubmed |
| pubmed-article:14600419 | pubmed:meshHeading | pubmed-meshheading:14600419... | lld:pubmed |
| pubmed-article:14600419 | pubmed:meshHeading | pubmed-meshheading:14600419... | lld:pubmed |
| pubmed-article:14600419 | pubmed:meshHeading | pubmed-meshheading:14600419... | lld:pubmed |
| pubmed-article:14600419 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14600419 | pubmed:articleTitle | Effect of quinine solutions on intracellular Ca2+ levels in neuro-2a cells--conventional physiological method for the evaluation of bitterness. | lld:pubmed |
| pubmed-article:14600419 | pubmed:affiliation | School of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Hyogo, Japan. | lld:pubmed |
| pubmed-article:14600419 | pubmed:publicationType | Journal Article | lld:pubmed |
