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pubmed-article:14587816pubmed:abstractTextOptical coherence microscopy (OCM) is demonstrated with a high-speed, broadband, reflective-grating phase modulator and a femtosecond Ti:Al2O3 laser. The novel system design permits high-resolution OCM imaging in a new operating regime in which a short coherence gate is used to relax the requirement for high-numerical-aperture confocal axial sectioning. In vivo cellular imaging is demonstrated in the Xenopus laevis tadpole and in human skin with a 3-microm coherence gate and a 30-microm confocal gate. The ability to achieve cellular imaging with a lower numerical aperture should facilitate the development of miniaturized probes for in vivo imaging applications.lld:pubmed
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pubmed-article:14587816pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:14587816pubmed:articleTitleHigh-resolution optical coherence microscopy for high-speed, in vivo cellular imaging.lld:pubmed
pubmed-article:14587816pubmed:affiliationDepartment of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.lld:pubmed
pubmed-article:14587816pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:14587816pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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