| pubmed-article:14586402 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14586402 | lifeskim:mentions | umls-concept:C0069117 | lld:lifeskim |
| pubmed-article:14586402 | lifeskim:mentions | umls-concept:C1512474 | lld:lifeskim |
| pubmed-article:14586402 | lifeskim:mentions | umls-concept:C1333655 | lld:lifeskim |
| pubmed-article:14586402 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:14586402 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:14586402 | lifeskim:mentions | umls-concept:C1707511 | lld:lifeskim |
| pubmed-article:14586402 | pubmed:issue | 49 | lld:pubmed |
| pubmed-article:14586402 | pubmed:dateCreated | 2003-10-30 | lld:pubmed |
| pubmed-article:14586402 | pubmed:abstractText | Histone deacetylase (HDAC) inhibitors cause growth arrest at the G1 and/or G2/M phases, and induce differentiation and/or apoptosis in a wide variety of tumour cells. The growth arrest at G1 phase by HDAC inhibitors is thought to be highly dependent on the upregulation of p21/WAF1, but the precise mechanism by which HDAC inhibitors cause G2/M arrest or apoptosis in tumour cells is unknown. Gadd45 causes cell cycle arrest at the G2/M phase transition and participates in genotoxic stress-induced apoptosis. We show here that it is also induced by a typical HDAC inhibitor, trichostatin A (TSA), through its promoter, in a p53-independent manner. To identify the mechanism of activation of the gadd45 promoter, we performed luciferase reporter analyses and electrophoretic mobility shift assays. These revealed that both the Oct-1 and CCAAT sites are needed for the full activation by TSA. We also found that the transcription factors Oct-1 and NF-Y specifically bind to each site. Thus, HDAC inhibitors can induce Gadd45 through its promoter without the need for functional p53, and both the Oct-1 and NF-Y concertedly participate in TSA-induced activation of the gadd45 promoter. | lld:pubmed |
| pubmed-article:14586402 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14586402 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14586402 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14586402 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14586402 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:14586402 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:14586402 | pubmed:author | pubmed-author:SakaiToshiyuk... | lld:pubmed |
| pubmed-article:14586402 | pubmed:author | pubmed-author:FuruichiKiyos... | lld:pubmed |
| pubmed-article:14586402 | pubmed:author | pubmed-author:SaitoShoichiS | lld:pubmed |
| pubmed-article:14586402 | pubmed:author | pubmed-author:SowaYoshihiro... | lld:pubmed |
| pubmed-article:14586402 | pubmed:author | pubmed-author:TakahashiSeny... | lld:pubmed |
| pubmed-article:14586402 | pubmed:author | pubmed-author:HiroseTohruT | lld:pubmed |
| pubmed-article:14586402 | pubmed:author | pubmed-author:YasudaChikako... | lld:pubmed |
| pubmed-article:14586402 | pubmed:author | pubmed-author:ShindoNobuaki... | lld:pubmed |
| pubmed-article:14586402 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14586402 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:14586402 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:14586402 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14586402 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14586402 | pubmed:pagination | 7762-73 | lld:pubmed |
| pubmed-article:14586402 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:14586402 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14586402 | pubmed:articleTitle | p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y. | lld:pubmed |
| pubmed-article:14586402 | pubmed:affiliation | Department of Preventive Medicine, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan. | lld:pubmed |
| pubmed-article:14586402 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14586402 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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