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pubmed-article:14586390pubmed:abstractTextThe ultimate mode of action by which nitroglycerin elicits vasodilation remains elusive. Animal studies point to an involvement of pertussis toxin-sensitive G proteins. The 825T allele of the GNB3 C825T polymorphism in the gene encoding the G protein beta3 subunit is associated with enhanced signal transduction via pertussis toxin-sensitive pathways in vitro. We hypothesized that G proteins have a role in nitroglycerin-mediated vasodilation and that carriers of the 825T allele would exhibit a stronger response to nitroglycerin.lld:pubmed
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pubmed-article:14586390pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:14586390pubmed:articleTitleVenous response to nitroglycerin is enhanced in young, healthy carriers of the 825T allele of the G protein beta3 subunit gene (GNB3).lld:pubmed
pubmed-article:14586390pubmed:affiliationDepartments of Nephrology & Hypertension and Pharmacology, Essen University, Essen, Germany. anna.mitchell@uni-esen.delld:pubmed
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