| pubmed-article:14585643 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14585643 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:14585643 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:14585643 | lifeskim:mentions | umls-concept:C1136031 | lld:lifeskim |
| pubmed-article:14585643 | pubmed:issue | 9393 | lld:pubmed |
| pubmed-article:14585643 | pubmed:dateCreated | 2003-10-30 | lld:pubmed |
| pubmed-article:14585643 | pubmed:abstractText | RNA interference (RNAi) is the sequence-specific gene-silencing induced by double-stranded RNA (dsRNA), and gives information about gene function quickly, easily, and inexpensively. The use of RNAi for genetic-based therapies is widely studied, especially in viral infections, cancers, and inherited genetic disorders. RNAi has been used to make tissue-specific knockdown mice for studying gene function in a whole animal. Combined with genomics data, RNAi-directed gene-silencing could allow functional determination of any gene expressed in a cell or pathway. The term RNAi came from the discovery that the injection of dsRNAs into Caenorhabditis elegans interferes with the expression of specific genes containing a complementary region to the delivered dsRNA. Although stalled for a time by the non-gene-specific interferon response elicited by dsRNA molecules longer than about 30 nucleotides in mammalian cells, Tom Tuschl's group found that transfection of synthetic 21-nucleotide small-interfering RNA (siRNA) duplexes were highly selective and sequence-specific inhibitors of endogenous genes. | lld:pubmed |
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| pubmed-article:14585643 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14585643 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14585643 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:14585643 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14585643 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:14585643 | pubmed:issn | 1474-547X | lld:pubmed |
| pubmed-article:14585643 | pubmed:author | pubmed-author:ShiYangY | lld:pubmed |
| pubmed-article:14585643 | pubmed:author | pubmed-author:WallNathan... | lld:pubmed |
| pubmed-article:14585643 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:14585643 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:14585643 | pubmed:volume | 362 | lld:pubmed |
| pubmed-article:14585643 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14585643 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14585643 | pubmed:pagination | 1401-3 | lld:pubmed |
| pubmed-article:14585643 | pubmed:dateRevised | 2011-8-25 | lld:pubmed |
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| pubmed-article:14585643 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14585643 | pubmed:articleTitle | Small RNA: can RNA interference be exploited for therapy? | lld:pubmed |
| pubmed-article:14585643 | pubmed:affiliation | Department of Pathology, Harvard Medical School, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:14585643 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14585643 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14585643 | pubmed:publicationType | Review | lld:pubmed |
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