Linked Life Data

14585285

Source:http://linkedlifedata.com/resource/pubmed/id/14585285

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:14585285rdf:typepubmed:Citationlld:pubmed
pubmed-article:14585285lifeskim:mentionsumls-concept:C0086418lld:lifeskim
pubmed-article:14585285lifeskim:mentionsumls-concept:C0027950lld:lifeskim
pubmed-article:14585285lifeskim:mentionsumls-concept:C1136310lld:lifeskim
pubmed-article:14585285lifeskim:mentionsumls-concept:C1366562lld:lifeskim
pubmed-article:14585285lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:14585285lifeskim:mentionsumls-concept:C2349975lld:lifeskim
pubmed-article:14585285lifeskim:mentionsumls-concept:C2911684lld:lifeskim
pubmed-article:14585285lifeskim:mentionsumls-concept:C0358321lld:lifeskim
pubmed-article:14585285lifeskim:mentionsumls-concept:C0185117lld:lifeskim
pubmed-article:14585285pubmed:issue11lld:pubmed
pubmed-article:14585285pubmed:dateCreated2003-10-30lld:pubmed
pubmed-article:14585285pubmed:abstractTextIntravenous human immunoglobulin therapy infrequently results in excessive inflammatory responses in vivo; these effects are not fully understood. We assessed whether sulfonated human immunoglobulin (SHIG) or polyethylene glycol-treated human immunoglobulin (PHIG) enhanced expression of inflammatory receptors on peripheral blood neutrophils in vitro, such as alphaMbeta2 (CD11b/CD18) and Fc gamma receptor type III (FcgammaRIII). CD11b and CD16 expression on neutrophils was measured by fluorescence flow cytometry. Various cytokines were assessed using a highly sensitive fluorescence microsphere system. SHIG enhanced/induced CD11b expression and partial aggregations on neutrophils, but PHIG did not. No detection of aggregation IgG was observed in SHIG and PHIG. SHIG-induced CD11b expression was inhibited by treatment of corticosteroid (dexamethasone) and by anti-CD16 monoclonal antibody. Concentrations of various cytokines such as interleukin (IL)-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, RANTES, tumor necrosis factor (TNF)-alpha, and interferon (INF)-gamma in culture supernatant were not significantly changed by SHIG or PHIG. SHIG and PHIG did not enhance CD16 on neutrophils. SHIG enhanced CD16-linked CD11b expression on neutrophils in vitro. CD11b induction was inhibited by dexamethasone and by anti-CD16 antibody. These in vitro results suggest that aggregations and enhancement of CD11b on neutrophils by SHIG may induce excessive inflammatory responses in vivo.lld:pubmed
pubmed-article:14585285pubmed:languageenglld:pubmed
pubmed-article:14585285pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14585285pubmed:citationSubsetIMlld:pubmed
pubmed-article:14585285pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14585285pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14585285pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14585285pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14585285pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14585285pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14585285pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14585285pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14585285pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14585285pubmed:statusMEDLINElld:pubmed
pubmed-article:14585285pubmed:issn1065-6995lld:pubmed
pubmed-article:14585285pubmed:authorpubmed-author:OkadaYasunori...lld:pubmed
pubmed-article:14585285pubmed:authorpubmed-author:KatoMasahikoMlld:pubmed
pubmed-article:14585285pubmed:authorpubmed-author:MorikawaAkihi...lld:pubmed
pubmed-article:14585285pubmed:authorpubmed-author:KimuraHirokaz...lld:pubmed
pubmed-article:14585285pubmed:authorpubmed-author:KozawaKunihis...lld:pubmed
pubmed-article:14585285pubmed:authorpubmed-author:OshimaShigeru...lld:pubmed
pubmed-article:14585285pubmed:authorpubmed-author:NaitoShigetoSlld:pubmed
pubmed-article:14585285pubmed:authorpubmed-author:TaniguchiKoic...lld:pubmed
pubmed-article:14585285pubmed:authorpubmed-author:NagaiAkiraAlld:pubmed
pubmed-article:14585285pubmed:authorpubmed-author:IkedaMiyukiMlld:pubmed
pubmed-article:14585285pubmed:issnTypePrintlld:pubmed
pubmed-article:14585285pubmed:volume27lld:pubmed
pubmed-article:14585285pubmed:ownerNLMlld:pubmed
pubmed-article:14585285pubmed:authorsCompleteYlld:pubmed
pubmed-article:14585285pubmed:pagination913-9lld:pubmed
pubmed-article:14585285pubmed:dateRevised2004-11-17lld:pubmed
pubmed-article:14585285pubmed:meshHeadingpubmed-meshheading:14585285...lld:pubmed
pubmed-article:14585285pubmed:meshHeadingpubmed-meshheading:14585285...lld:pubmed
pubmed-article:14585285pubmed:meshHeadingpubmed-meshheading:14585285...lld:pubmed
pubmed-article:14585285pubmed:meshHeadingpubmed-meshheading:14585285...lld:pubmed
pubmed-article:14585285pubmed:meshHeadingpubmed-meshheading:14585285...lld:pubmed
pubmed-article:14585285pubmed:meshHeadingpubmed-meshheading:14585285...lld:pubmed
pubmed-article:14585285pubmed:meshHeadingpubmed-meshheading:14585285...lld:pubmed
pubmed-article:14585285pubmed:meshHeadingpubmed-meshheading:14585285...lld:pubmed
pubmed-article:14585285pubmed:meshHeadingpubmed-meshheading:14585285...lld:pubmed
pubmed-article:14585285pubmed:meshHeadingpubmed-meshheading:14585285...lld:pubmed
pubmed-article:14585285pubmed:meshHeadingpubmed-meshheading:14585285...lld:pubmed
pubmed-article:14585285pubmed:meshHeadingpubmed-meshheading:14585285...lld:pubmed
pubmed-article:14585285pubmed:meshHeadingpubmed-meshheading:14585285...lld:pubmed
pubmed-article:14585285pubmed:year2003lld:pubmed
pubmed-article:14585285pubmed:articleTitleSulfonated human immunoglobulin enhances CD16-linked CD11b expression on human neutrophils.lld:pubmed
pubmed-article:14585285pubmed:affiliationGunma Prefectural Institute of Public Health and Environmental Sciences, 378, Kamioki, Maebashi, Gunma 371-0052, Japan. kimura-hi@pref.gunma.jplld:pubmed
pubmed-article:14585285pubmed:publicationTypeJournal Articlelld:pubmed