| pubmed-article:14583787 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14583787 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:14583787 | lifeskim:mentions | umls-concept:C0017638 | lld:lifeskim |
| pubmed-article:14583787 | lifeskim:mentions | umls-concept:C0599733 | lld:lifeskim |
| pubmed-article:14583787 | lifeskim:mentions | umls-concept:C0525037 | lld:lifeskim |
| pubmed-article:14583787 | lifeskim:mentions | umls-concept:C0034538 | lld:lifeskim |
| pubmed-article:14583787 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:14583787 | lifeskim:mentions | umls-concept:C0205161 | lld:lifeskim |
| pubmed-article:14583787 | lifeskim:mentions | umls-concept:C1517499 | lld:lifeskim |
| pubmed-article:14583787 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:14583787 | pubmed:dateCreated | 2003-10-29 | lld:pubmed |
| pubmed-article:14583787 | pubmed:abstractText | It is well established that cells synchronised at the G1-S phase are highly radiosensitive. In this study, p16-null human glioma cell lines were induced into G1 cell cycle arrest by adenovirus-mediated p16 gene transfer, and examined for radiation-induced cell killing. Clonogenic analysis and trypan blue extraction test showed that the p16 gene transfer enhanced radiation-induced cell killing in p16-null glioma cell lines. TUNEL assays and pulse-field gel electrophoresis confirmed that the radiation-induced cell killing of p16-transfected cells could be caused by a nonapoptotic mechanism. Gimsa staining demonstrated that irradiation alone or Ax-mock infection plus irradiation results in a slight increase in the frequency of cells with abnormal nucleus, compared to unirradiated uninfected or Ax-mock infected cells. However, Ax-hp16 or Ax-hp21 infection alone modestly increased the frequency of cells with abnormal nucleus (especially bi- and multinucleation), and 4-Gy irradiation of Ax-hp16 or Ax-hp21 infected cells substantially enhanced this frequency. These results suggest that there exists some unknown interaction between radiation and p16 in cytoplasm/membranes, which decreases cytokinesis and promotes abnormal nucleation. Thus, p16 expression prevented radiation-induced apoptosis by promoting abnormal nucleation, thereby leading to another mode of cell death. | lld:pubmed |
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| pubmed-article:14583787 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14583787 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14583787 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14583787 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14583787 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14583787 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:14583787 | pubmed:author | pubmed-author:MatsuuraSS | lld:pubmed |
| pubmed-article:14583787 | pubmed:author | pubmed-author:YoshiokaHH | lld:pubmed |
| pubmed-article:14583787 | pubmed:author | pubmed-author:HamaSS | lld:pubmed |
| pubmed-article:14583787 | pubmed:author | pubmed-author:TauchiHH | lld:pubmed |
| pubmed-article:14583787 | pubmed:author | pubmed-author:AritaKK | lld:pubmed |
| pubmed-article:14583787 | pubmed:author | pubmed-author:KajiwaraYY | lld:pubmed |
| pubmed-article:14583787 | pubmed:author | pubmed-author:YamasakiFF | lld:pubmed |
| pubmed-article:14583787 | pubmed:author | pubmed-author:KurisuKK | lld:pubmed |
| pubmed-article:14583787 | pubmed:author | pubmed-author:MandaiKK | lld:pubmed |
| pubmed-article:14583787 | pubmed:author | pubmed-author:HeikeYY | lld:pubmed |
| pubmed-article:14583787 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14583787 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:14583787 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:14583787 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14583787 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14583787 | pubmed:pagination | 1802-11 | lld:pubmed |
| pubmed-article:14583787 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:14583787 | pubmed:meshHeading | pubmed-meshheading:14583787... | lld:pubmed |
| pubmed-article:14583787 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14583787 | pubmed:articleTitle | p16 Gene transfer increases cell killing with abnormal nucleation after ionising radiation in glioma cells. | lld:pubmed |
| pubmed-article:14583787 | pubmed:affiliation | Department of Neurosurgery, Hiroshima University School of Medicine, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan. ml-hns@hiroshima-u.ac.jp | lld:pubmed |
| pubmed-article:14583787 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14583787 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:14583787 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14583787 | lld:pubmed |
