pubmed-article:14580391 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:14580391 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
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pubmed-article:14580391 | lifeskim:mentions | umls-concept:C0018494 | lld:lifeskim |
pubmed-article:14580391 | lifeskim:mentions | umls-concept:C0814997 | lld:lifeskim |
pubmed-article:14580391 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
pubmed-article:14580391 | lifeskim:mentions | umls-concept:C0449943 | lld:lifeskim |
pubmed-article:14580391 | lifeskim:mentions | umls-concept:C1550548 | lld:lifeskim |
pubmed-article:14580391 | lifeskim:mentions | umls-concept:C1555714 | lld:lifeskim |
pubmed-article:14580391 | lifeskim:mentions | umls-concept:C1705654 | lld:lifeskim |
pubmed-article:14580391 | pubmed:issue | 6 | lld:pubmed |
pubmed-article:14580391 | pubmed:dateCreated | 2003-10-28 | lld:pubmed |
pubmed-article:14580391 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14580391 | pubmed:abstractText | Some strains of Salmonella enterica serovar Dublin are Vi antigen-positive. S. enterica serovar Typhi uses Type IVB pili, encoded adjacent to the viaB locus required for Vi antigen synthesis, to facilitate both eukaryotic cell attachment and bacterial self-association under conditions that favour DNA supercoiling. These pilus-mediated events may be important in typhoid fever pathogenesis. A survey of 17 isolates of S. enterica serovar Dublin showed that all strains which carried the viaB region also carried a serovar Typhi-like Type IVB pil operon, and all serovar Dublin Vi antigen-negative isolates lacked the pil operon. The pil operon was completely sequenced from one of the Vi(+) serovar Dublin strains, and was almost identical (4 nt changes; 3 aa changes, in over 10 kb) to that of serovar Typhi. A pilS mutant of one serovar Dublin strain was constructed, and shown to invade cultured human intestinal INT407 cells to an extent only 20% that of the wild-type parent. Purified prePilS protein inhibited INT407 cell entry by serovar Dublin. The wild-type serovar Dublin strain, but not the pilS mutant, self-associated. The data suggest that the serovar Dublin Type IVB pil operon may increase the human-invasiveness of serovar Dublin, compared to pil-free strains. | lld:pubmed |
pubmed-article:14580391 | pubmed:language | eng | lld:pubmed |
pubmed-article:14580391 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14580391 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:14580391 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:14580391 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:14580391 | pubmed:month | Dec | lld:pubmed |
pubmed-article:14580391 | pubmed:issn | 0882-4010 | lld:pubmed |
pubmed-article:14580391 | pubmed:author | pubmed-author:WallisTimothy... | lld:pubmed |
pubmed-article:14580391 | pubmed:author | pubmed-author:JonesPhilip... | lld:pubmed |
pubmed-article:14580391 | pubmed:author | pubmed-author:MorrisChristi... | lld:pubmed |
pubmed-article:14580391 | pubmed:author | pubmed-author:HackettJimJ | lld:pubmed |
pubmed-article:14580391 | pubmed:author | pubmed-author:TamConnie K... | lld:pubmed |
pubmed-article:14580391 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:14580391 | pubmed:volume | 35 | lld:pubmed |
pubmed-article:14580391 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:14580391 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:14580391 | pubmed:pagination | 279-84 | lld:pubmed |
pubmed-article:14580391 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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pubmed-article:14580391 | pubmed:year | 2003 | lld:pubmed |
pubmed-article:14580391 | pubmed:articleTitle | Salmonella enterica serovar Dublin strains which are Vi antigen-positive use type IVB pili for bacterial self-association and human intestinal cell entry. | lld:pubmed |
pubmed-article:14580391 | pubmed:affiliation | Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China. bctina@ust.hk | lld:pubmed |
pubmed-article:14580391 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:14580391 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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