| pubmed-article:14576281 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14576281 | lifeskim:mentions | umls-concept:C0162741 | lld:lifeskim |
| pubmed-article:14576281 | lifeskim:mentions | umls-concept:C0014442 | lld:lifeskim |
| pubmed-article:14576281 | lifeskim:mentions | umls-concept:C0036027 | lld:lifeskim |
| pubmed-article:14576281 | lifeskim:mentions | umls-concept:C0311400 | lld:lifeskim |
| pubmed-article:14576281 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:14576281 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:14576281 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:14576281 | lifeskim:mentions | umls-concept:C1156685 | lld:lifeskim |
| pubmed-article:14576281 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:14576281 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14576281 | pubmed:dateCreated | 2003-11-12 | lld:pubmed |
| pubmed-article:14576281 | pubmed:abstractText | In plants, excess cellular lysine (Lys) is catabolized into glutamic acid and acetyl-coenzyme A; yet, it is still not clear whether this pathway has other functions in addition to balancing Lys levels. To address this issue, we examined the effects of stress-related hormones, abscisic acid (ABA), and jasmonate, as well as various metabolic signals on the production of the mRNA and polypeptide of the bifunctional Lys-ketoglutarate reductase (LKR)/saccharopine dehydrogenase (SDH) enzyme, which contains the first two linked enzymes of Lys catabolism. The level of LKR/SDH was strongly enhanced by ABA, jasmonate, and sugar starvation, whereas excess sugars and nitrogen starvation reduced its level; thus this pathway appears to fulfill multiple functions in stress-related and carbon/nitrogen metabolism. Treatments with combination of hormones and/or metabolites, as well as use of ABA mutants in conjunction with the tester sugars mannose and 3-O-methyl-glucose further supported the idea that the hormonal and metabolic signals apparently operate through different signal transduction cascades. The stimulation of LKR/SDH protein expression by ABA is regulated by a signal transduction cascade that contains the ABI1-1 and ABI2-1 protein phosphatases. By contrast, the stimulation of LKR/SDH protein expression by sugar starvation is regulated by the hexokinase-signaling cascade in a similar manner to the repression of many photosynthetic genes by sugars. These findings suggest a metabolic and mechanistic link between Lys catabolism and photosynthesis-related metabolism in the regulation of carbon/nitrogen partitioning. | lld:pubmed |
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| pubmed-article:14576281 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14576281 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14576281 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14576281 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14576281 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14576281 | pubmed:issn | 0032-0889 | lld:pubmed |
| pubmed-article:14576281 | pubmed:author | pubmed-author:GaliliGadG | lld:pubmed |
| pubmed-article:14576281 | pubmed:author | pubmed-author:StepanskyAsya... | lld:pubmed |
| pubmed-article:14576281 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14576281 | pubmed:volume | 133 | lld:pubmed |
| pubmed-article:14576281 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14576281 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14576281 | pubmed:pagination | 1407-15 | lld:pubmed |
| pubmed-article:14576281 | pubmed:dateRevised | 2010-9-20 | lld:pubmed |
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| pubmed-article:14576281 | pubmed:meshHeading | pubmed-meshheading:14576281... | lld:pubmed |
| pubmed-article:14576281 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14576281 | pubmed:articleTitle | Synthesis of the Arabidopsis bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase enzyme of lysine catabolism is concertedly regulated by metabolic and stress-associated signals. | lld:pubmed |
| pubmed-article:14576281 | pubmed:affiliation | Department of Plant Sciences, The Weizmann Institute of Science, Rehovot 76100 Israel. | lld:pubmed |
| pubmed-article:14576281 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14576281 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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