Linked Life Data

14563400

Source:http://linkedlifedata.com/resource/pubmed/id/14563400

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pubmed-article:14563400pubmed:abstractTextConjugated linoleic acid (CLA) is the term given to a group of positional and geometric isomers of the essential fatty acid linoleic acid. CLA is found naturally in foods such as dairy and meat products. CLA is reported to have a number of beneficial effects including anticarcinogenic activity. However, safety data are limited. Clarinol G80 is a commercial preparation containing equal amounts of the 9cis,11trans and 10trans,12cis CLA isomers in the form of glycerides. In order to support the safety-in-use of Clarinol G80 as an ingredient in food, the preparation was tested in two in vitro mutagenicity assays, an Ames test and an in vitro cytogenetics assay, and a 90-day repeat-dose oral toxicity rat study. Clarinol G80 was non-mutagenic in both in vitro assays. In the 90-day study, Clarinol G80 produced hepatocellular hypertrophy in female rats at the highest dose level (15% w/w). This effect was an adaptive effect in response to feeding high levels of Clarinol G80 in the diet and was reversible upon withdrawal of test material. An increase in plasma insulin levels was also observed female rats fed 15% w/w Clarinol G80 but there was no effect on plasma glucose levels. A No Observed Adverse Effect Level of 2433 mg/kg bw/day for male and 2728 mg/kg bw/day female rats was identified in the study.lld:pubmed
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pubmed-article:14563400pubmed:articleTitleA subchronic 90-day oral rat toxicity study and in vitro genotoxicity studies with a conjugated linoleic acid product.lld:pubmed
pubmed-article:14563400pubmed:affiliationSafety and Environmental Assurance Centre, Unilever, Colworth House, Sharnbrook, Bedfordshire MK44 1LQ, UK.lld:pubmed
pubmed-article:14563400pubmed:publicationTypeJournal Articlelld:pubmed
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