| pubmed-article:1456090 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1456090 | lifeskim:mentions | umls-concept:C0024554 | lld:lifeskim |
| pubmed-article:1456090 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:1456090 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:1456090 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1456090 | lifeskim:mentions | umls-concept:C0005938 | lld:lifeskim |
| pubmed-article:1456090 | lifeskim:mentions | umls-concept:C0015811 | lld:lifeskim |
| pubmed-article:1456090 | lifeskim:mentions | umls-concept:C0020619 | lld:lifeskim |
| pubmed-article:1456090 | lifeskim:mentions | umls-concept:C0006668 | lld:lifeskim |
| pubmed-article:1456090 | lifeskim:mentions | umls-concept:C0040165 | lld:lifeskim |
| pubmed-article:1456090 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1456090 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:1456090 | lifeskim:mentions | umls-concept:C0442802 | lld:lifeskim |
| pubmed-article:1456090 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:1456090 | pubmed:dateCreated | 1992-12-31 | lld:pubmed |
| pubmed-article:1456090 | pubmed:abstractText | Excess thyroid hormone decreases bone mineral density (BMD), a potential problem in managing patients with differentiated thyroid carcinoma and nontoxic goiter who require lifelong TSH-suppressive doses of thyroid hormone. We studied the effect of thyroid hormone excess on vertebral and femoral BMD and the role of hypogonadism in modulating this effect in a rat model. The potential role of calcitonin (CT) in preventing thyroid hormone-associated bone loss was also investigated. A total of 40 male Sprague-Dawley rats were divided into four groups. Groups 1 and 2 were orchidectomized (ORX); groups 3 and 4 were sham operated (SO). Groups 1 and 3 received 20 micrograms intraperitoneal L-thyroxine (L-T4) per 100 g body weight daily for 3 weeks; groups 2 and 4 received vehicle IP. Another 40 rats were divided into four groups. Groups 1 and 2 received L-T4, and groups 1 and 3 received CT, 2.5 U per 100 g body weight, subcutaneously (SC) daily for 3 weeks. BMD of the L4 and 5 and the right femur were measured by dual-energy x-ray absorptiometry at baseline and at the end of the study. Orchidectomy decreased femoral (P < 0.05) but not lumbar BMD. The administration of excess L-T4 decreased femoral (cortical) BMD in both SO (P < 0.05) and ORX rats (P < 0.05) without affecting lumbar (trabecular) BMD. CT increased lumbar BMD in both vehicle (P < 0.001) and L-T4-treated rats (P < 0.001). However, CT did not affect femoral BMD in vehicle-treated rats and did not prevent the L-T4-induced femoral bone loss.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:1456090 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1456090 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1456090 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1456090 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1456090 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1456090 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1456090 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1456090 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1456090 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1456090 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1456090 | pubmed:issn | 0884-0431 | lld:pubmed |
| pubmed-article:1456090 | pubmed:author | pubmed-author:BravermanL... | lld:pubmed |
| pubmed-article:1456090 | pubmed:author | pubmed-author:AlexSS | lld:pubmed |
| pubmed-article:1456090 | pubmed:author | pubmed-author:BaranD TDT | lld:pubmed |
| pubmed-article:1456090 | pubmed:author | pubmed-author:Ongphiphadhan... | lld:pubmed |
| pubmed-article:1456090 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1456090 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:1456090 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1456090 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1456090 | pubmed:pagination | 1227-31 | lld:pubmed |
| pubmed-article:1456090 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1456090 | pubmed:meshHeading | pubmed-meshheading:1456090-... | lld:pubmed |
| pubmed-article:1456090 | pubmed:meshHeading | pubmed-meshheading:1456090-... | lld:pubmed |
| pubmed-article:1456090 | pubmed:meshHeading | pubmed-meshheading:1456090-... | lld:pubmed |
| pubmed-article:1456090 | pubmed:meshHeading | pubmed-meshheading:1456090-... | lld:pubmed |
| pubmed-article:1456090 | pubmed:meshHeading | pubmed-meshheading:1456090-... | lld:pubmed |
| pubmed-article:1456090 | pubmed:meshHeading | pubmed-meshheading:1456090-... | lld:pubmed |
| pubmed-article:1456090 | pubmed:meshHeading | pubmed-meshheading:1456090-... | lld:pubmed |
| pubmed-article:1456090 | pubmed:meshHeading | pubmed-meshheading:1456090-... | lld:pubmed |
| pubmed-article:1456090 | pubmed:meshHeading | pubmed-meshheading:1456090-... | lld:pubmed |
| pubmed-article:1456090 | pubmed:meshHeading | pubmed-meshheading:1456090-... | lld:pubmed |
| pubmed-article:1456090 | pubmed:meshHeading | pubmed-meshheading:1456090-... | lld:pubmed |
| pubmed-article:1456090 | pubmed:meshHeading | pubmed-meshheading:1456090-... | lld:pubmed |
| pubmed-article:1456090 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1456090 | pubmed:articleTitle | Excessive L-thyroxine therapy decreases femoral bone mineral densities in the male rat: effect of hypogonadism and calcitonin. | lld:pubmed |
| pubmed-article:1456090 | pubmed:affiliation | Division of Endocrinology and Metabolism, University of Massachusetts Medical School, Worcester. | lld:pubmed |
| pubmed-article:1456090 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1456090 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1456090 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
