| pubmed-article:14560022 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14560022 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:14560022 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:14560022 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:14560022 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:14560022 | lifeskim:mentions | umls-concept:C1417595 | lld:lifeskim |
| pubmed-article:14560022 | lifeskim:mentions | umls-concept:C1417612 | lld:lifeskim |
| pubmed-article:14560022 | lifeskim:mentions | umls-concept:C1538038 | lld:lifeskim |
| pubmed-article:14560022 | lifeskim:mentions | umls-concept:C1538310 | lld:lifeskim |
| pubmed-article:14560022 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:14560022 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:14560022 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:14560022 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:14560022 | pubmed:dateCreated | 2003-10-15 | lld:pubmed |
| pubmed-article:14560022 | pubmed:abstractText | The IkappaB kinase (IKK)-related kinase NAK (also known as TBK or T2K) contributes to the activation of NF-kappaB-dependent gene expression. Here we identify NAP1 (for NAK-associated protein 1), a protein that interacts with NAK and its relative IKK epsilon (also known as IKKi). NAP1 activates NAK and facilitates its oligomerization. Interestingly, the NAK-NAP1 complex itself effectively phosphorylated serine 536 of the p65/RelA subunit of NF-kappaB, and this activity was stimulated by tumor necrosis factor alpha (TNF-alpha). Overexpression of NAP1 specifically enhanced cytokine induction of an NF-kappaB-dependent, but not an AP-1-dependent, reporter. Depletion of NAP1 reduced NF-kappaB-dependent reporter gene expression and sensitized cells to TNF-alpha-induced apoptosis. These results define NAP1 as an activator of IKK-related kinases and suggest that the NAK-NAP1 complex may protect cells from TNF-alpha-induced apoptosis by promoting NF-kappaB activation. | lld:pubmed |
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| pubmed-article:14560022 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14560022 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560022 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14560022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14560022 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14560022 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14560022 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:14560022 | pubmed:author | pubmed-author:SakuraiHiroak... | lld:pubmed |
| pubmed-article:14560022 | pubmed:author | pubmed-author:JohTakashiT | lld:pubmed |
| pubmed-article:14560022 | pubmed:author | pubmed-author:ItohMakotoM | lld:pubmed |
| pubmed-article:14560022 | pubmed:author | pubmed-author:KatoTakashiT | lld:pubmed |
| pubmed-article:14560022 | pubmed:author | pubmed-author:KarinMichaelM | lld:pubmed |
| pubmed-article:14560022 | pubmed:author | pubmed-author:TaniguchiYuko... | lld:pubmed |
| pubmed-article:14560022 | pubmed:author | pubmed-author:DelhaseMireil... | lld:pubmed |
| pubmed-article:14560022 | pubmed:author | pubmed-author:NakanishiMako... | lld:pubmed |
| pubmed-article:14560022 | pubmed:author | pubmed-author:FujitaFumitak... | lld:pubmed |
| pubmed-article:14560022 | pubmed:author | pubmed-author:FuruyaAkikoA | lld:pubmed |
