| pubmed-article:14560020 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14560020 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:14560020 | lifeskim:mentions | umls-concept:C0040845 | lld:lifeskim |
| pubmed-article:14560020 | lifeskim:mentions | umls-concept:C1412058 | lld:lifeskim |
| pubmed-article:14560020 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:14560020 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:14560020 | pubmed:dateCreated | 2003-10-15 | lld:pubmed |
| pubmed-article:14560020 | pubmed:abstractText | ABCA1, the mutant molecule in Tangier Disease, mediates efflux of cellular cholesterol to apoA-I and is induced by liver X receptor (LXR)/retinoid X receptor (RXR) transcription factors. Retinoic acid receptor (RAR) activators (all-trans-retinoic acid [ATRA] and TTNPB) were found to increase ATP-binding cassette transporter 1 (ABCA1) mRNA and protein in macrophages. In cellular cotransfection assays, RARgamma/RXR activated the human ABCA1 promoter, via the same direct repeat 4 (DR4) promoter element as LXR/RXR. Chromatin immunoprecipitation analysis in macrophages confirmed the binding of RARgamma/RXR to the ABCA1 promoter DR4 element in the presence of ATRA, with weaker binding of RARalpha/RXR, and no binding of RARbeta/RXR. However, in macrophages from RARgamma(-/-) mice, TTNPB still induced ABCA1, in association with marked upregulation of RARalpha, suggesting that high levels of RARalpha can compensate for the absence of RARgamma. Dose-response experiments with ATRA in mouse primary macrophages showed that other LXR target genes were weakly induced (ABCG1 and SREBP-1c) or not induced (apoE and LXRalpha). The more specific RAR activator TTNPB did not induce SREBP-1c in mouse primary macrophages or liver. These studies indicate a direct role of RARgamma/RXR in induction of macrophage ABCA1. | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14560020 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14560020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560020 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14560020 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14560020 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:14560020 | pubmed:author | pubmed-author:LundErik GEG | lld:pubmed |
| pubmed-article:14560020 | pubmed:author | pubmed-author:FuXuanX | lld:pubmed |
| pubmed-article:14560020 | pubmed:author | pubmed-author:GudasLorraine... | lld:pubmed |
| pubmed-article:14560020 | pubmed:author | pubmed-author:TallAlan RAR | lld:pubmed |
| pubmed-article:14560020 | pubmed:author | pubmed-author:LalanneFloren... | lld:pubmed |
| pubmed-article:14560020 | pubmed:author | pubmed-author:CostetPhilipp... | lld:pubmed |
| pubmed-article:14560020 | pubmed:author | pubmed-author:Gerbod-Gianno... | lld:pubmed |
| pubmed-article:14560020 | pubmed:author | pubmed-author:MolinaJennife... | lld:pubmed |
| pubmed-article:14560020 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14560020 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:14560020 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14560020 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14560020 | pubmed:pagination | 7756-66 | lld:pubmed |
| pubmed-article:14560020 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:14560020 | pubmed:meshHeading | pubmed-meshheading:14560020... | lld:pubmed |
| pubmed-article:14560020 | pubmed:meshHeading | pubmed-meshheading:14560020... | lld:pubmed |
| pubmed-article:14560020 | pubmed:meshHeading | pubmed-meshheading:14560020... | lld:pubmed |
| pubmed-article:14560020 | pubmed:meshHeading | pubmed-meshheading:14560020... | lld:pubmed |
| pubmed-article:14560020 | pubmed:meshHeading | pubmed-meshheading:14560020... | lld:pubmed |
| pubmed-article:14560020 | pubmed:meshHeading | pubmed-meshheading:14560020... | lld:pubmed |
| pubmed-article:14560020 | pubmed:meshHeading | pubmed-meshheading:14560020... | lld:pubmed |
| pubmed-article:14560020 | pubmed:meshHeading | pubmed-meshheading:14560020... | lld:pubmed |
| pubmed-article:14560020 | pubmed:meshHeading | pubmed-meshheading:14560020... | lld:pubmed |
| pubmed-article:14560020 | pubmed:meshHeading | pubmed-meshheading:14560020... | lld:pubmed |
| pubmed-article:14560020 | pubmed:meshHeading | pubmed-meshheading:14560020... | lld:pubmed |
| pubmed-article:14560020 | pubmed:meshHeading | pubmed-meshheading:14560020... | lld:pubmed |
