| pubmed-article:14550922 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14550922 | lifeskim:mentions | umls-concept:C0038454 | lld:lifeskim |
| pubmed-article:14550922 | lifeskim:mentions | umls-concept:C0012984 | lld:lifeskim |
| pubmed-article:14550922 | lifeskim:mentions | umls-concept:C0080103 | lld:lifeskim |
| pubmed-article:14550922 | lifeskim:mentions | umls-concept:C0596981 | lld:lifeskim |
| pubmed-article:14550922 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:14550922 | lifeskim:mentions | umls-concept:C0228174 | lld:lifeskim |
| pubmed-article:14550922 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
| pubmed-article:14550922 | lifeskim:mentions | umls-concept:C0524851 | lld:lifeskim |
| pubmed-article:14550922 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:14550922 | lifeskim:mentions | umls-concept:C0136157 | lld:lifeskim |
| pubmed-article:14550922 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14550922 | pubmed:dateCreated | 2003-10-10 | lld:pubmed |
| pubmed-article:14550922 | pubmed:abstractText | Considerable evidence is accumulating to suggest that in vivo formation of free radicals in the brain, such as peroxynitrite (ONOO-), and programmed cell death (i.e. apoptosis) play important roles in neurodegeneration and stroke. However, it is not known whether ONOO- can induce apoptosis in cerebral vascular smooth muscle cells (CVSMCs). The present study was designed to determine whether or not canine CVSMCs undergo apoptosis following treatment with ONOO-. Direct exposure of canine CVSMCs to ONOO- induced apoptosis in a concentration-dependent manner, as confirmed by means of fluorescence staining, TdT-mediated dUTP nick-end labeling and comet assays. Peroxynitrite treatment resulted in an elevation of [Ca2+]i in the CVSMCs. Peroxynitrite-induced apoptosis may thus be brought about by activation of Ca2+-dependent endonucleases. Although the precise mechanisms by which peroxynitrite induces apoptosis need to be further investigated, the present findings could be used to suggest that ONOO- formation in the brain may play important roles in neurodegenerative processes and strokes via detrimental actions on cerebral microvessels and blood flow. | lld:pubmed |
| pubmed-article:14550922 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14550922 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14550922 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14550922 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14550922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14550922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14550922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14550922 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14550922 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:14550922 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:14550922 | pubmed:author | pubmed-author:LiuWeiminW | lld:pubmed |
| pubmed-article:14550922 | pubmed:author | pubmed-author:LiJianfengJ | lld:pubmed |
| pubmed-article:14550922 | pubmed:author | pubmed-author:AlturaBella... | lld:pubmed |
| pubmed-article:14550922 | pubmed:author | pubmed-author:AlturaBurton... | lld:pubmed |
| pubmed-article:14550922 | pubmed:author | pubmed-author:LiWenyanW | lld:pubmed |
| pubmed-article:14550922 | pubmed:author | pubmed-author:SuJialinJ | lld:pubmed |
| pubmed-article:14550922 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14550922 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:14550922 | pubmed:volume | 350 | lld:pubmed |
| pubmed-article:14550922 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14550922 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14550922 | pubmed:pagination | 173-7 | lld:pubmed |
| pubmed-article:14550922 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:14550922 | pubmed:meshHeading | pubmed-meshheading:14550922... | lld:pubmed |
| pubmed-article:14550922 | pubmed:meshHeading | pubmed-meshheading:14550922... | lld:pubmed |
| pubmed-article:14550922 | pubmed:meshHeading | pubmed-meshheading:14550922... | lld:pubmed |
| pubmed-article:14550922 | pubmed:meshHeading | pubmed-meshheading:14550922... | lld:pubmed |
| pubmed-article:14550922 | pubmed:meshHeading | pubmed-meshheading:14550922... | lld:pubmed |
| pubmed-article:14550922 | pubmed:meshHeading | pubmed-meshheading:14550922... | lld:pubmed |
| pubmed-article:14550922 | pubmed:meshHeading | pubmed-meshheading:14550922... | lld:pubmed |
| pubmed-article:14550922 | pubmed:meshHeading | pubmed-meshheading:14550922... | lld:pubmed |
| pubmed-article:14550922 | pubmed:meshHeading | pubmed-meshheading:14550922... | lld:pubmed |
| pubmed-article:14550922 | pubmed:meshHeading | pubmed-meshheading:14550922... | lld:pubmed |
| pubmed-article:14550922 | pubmed:meshHeading | pubmed-meshheading:14550922... | lld:pubmed |
| pubmed-article:14550922 | pubmed:meshHeading | pubmed-meshheading:14550922... | lld:pubmed |
| pubmed-article:14550922 | pubmed:meshHeading | pubmed-meshheading:14550922... | lld:pubmed |
| pubmed-article:14550922 | pubmed:meshHeading | pubmed-meshheading:14550922... | lld:pubmed |
| pubmed-article:14550922 | pubmed:meshHeading | pubmed-meshheading:14550922... | lld:pubmed |
| pubmed-article:14550922 | pubmed:meshHeading | pubmed-meshheading:14550922... | lld:pubmed |
| pubmed-article:14550922 | pubmed:meshHeading | pubmed-meshheading:14550922... | lld:pubmed |
| pubmed-article:14550922 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14550922 | pubmed:articleTitle | Peroxynitrite induces apoptosis in canine cerebral vascular muscle cells: possible relation to neurodegenerative diseases and strokes. | lld:pubmed |
| pubmed-article:14550922 | pubmed:affiliation | Department of Physiology and Pharmacology, State University of New York Downstate Medical Center, Health Science Center at Brooklyn, 450 Clarkson Avenue, Brooklyn, NY 11203, USA. | lld:pubmed |
| pubmed-article:14550922 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14550922 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14550922 | lld:pubmed |
