| pubmed-article:1454824 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1454824 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:1454824 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:1454824 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:1454824 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:1454824 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:1454824 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:1454824 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:1454824 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:1454824 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:1454824 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:1454824 | lifeskim:mentions | umls-concept:C0162388 | lld:lifeskim |
| pubmed-article:1454824 | lifeskim:mentions | umls-concept:C0443288 | lld:lifeskim |
| pubmed-article:1454824 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:1454824 | pubmed:dateCreated | 1993-1-7 | lld:pubmed |
| pubmed-article:1454824 | pubmed:abstractText | Cytotoxic T lymphocytes (CTLs) recognize major histocompatibility complex (MHC) class I molecules, normally composed of a heavy chain, a beta 2-microglobulin (beta 2m), and peptide antigens. beta 2m is considered essential for the assembly and intracellular transport of MHC class I molecules as well as their peptide presentation to CTLs. Contrary to this dogma, we now report the generation of allospecific and restricted CD8+ and TCR alpha beta+ CTLs (where TCR is T-cell receptor) capable of killing beta 2m-deficient cells. Such CTLs were obtained by priming mice with live allogeneic beta 2m- spleen cells or mutant lymphoma cells producing MHC class I protein but no detectable beta 2m. Although both beta 2m- and beta 2m-expressing lymphoma cells were rejected in allogeneic mice, only the former were efficient inducers of CTLs recognizing beta 2m- cells. These CTLs were MHC class I (H-2Kb or Db)-specific and CD8-dependent and did not require serum as a source of external beta 2m in the culture. They could be induced across major and minor histocompatibility barriers. The H-2-restricted CTLs generated in the latter case failed to kill the antigen-processing-deficient target RMA-S cells. The results show that MHC class I heavy chains in beta 2m- cells can be transported to the cell surface and act as antigens or antigen-presenting molecules to allospecific and MHC-restricted CTLs. | lld:pubmed |
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| pubmed-article:1454824 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1454824 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1454824 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1454824 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1454824 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1454824 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:1454824 | pubmed:author | pubmed-author:KärreKK | lld:pubmed |
| pubmed-article:1454824 | pubmed:author | pubmed-author:KollerBB | lld:pubmed |
| pubmed-article:1454824 | pubmed:author | pubmed-author:GladMM | lld:pubmed |
| pubmed-article:1454824 | pubmed:author | pubmed-author:HöglundPP | lld:pubmed |
| pubmed-article:1454824 | pubmed:author | pubmed-author:FrankssonLL | lld:pubmed |
| pubmed-article:1454824 | pubmed:author | pubmed-author:OhlénCC | lld:pubmed |
| pubmed-article:1454824 | pubmed:author | pubmed-author:LjunggrenH... | lld:pubmed |
| pubmed-article:1454824 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1454824 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1454824 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:1454824 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1454824 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1454824 | pubmed:pagination | 11381-5 | lld:pubmed |
| pubmed-article:1454824 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1454824 | pubmed:meshHeading | pubmed-meshheading:1454824-... | lld:pubmed |
| pubmed-article:1454824 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1454824 | pubmed:articleTitle | Major histocompatibility complex class I-specific and -restricted killing of beta 2-microglobulin-deficient cells by CD8+ cytotoxic T lymphocytes. | lld:pubmed |
| pubmed-article:1454824 | pubmed:affiliation | Department of Tumor Biology, Karolinska Institutet, Stockholm, Sweden. | lld:pubmed |
| pubmed-article:1454824 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1454824 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1454824 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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