| pubmed-article:14530522 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14530522 | lifeskim:mentions | umls-concept:C0021051 | lld:lifeskim |
| pubmed-article:14530522 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:14530522 | lifeskim:mentions | umls-concept:C0175677 | lld:lifeskim |
| pubmed-article:14530522 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:14530522 | lifeskim:mentions | umls-concept:C0229664 | lld:lifeskim |
| pubmed-article:14530522 | lifeskim:mentions | umls-concept:C0181078 | lld:lifeskim |
| pubmed-article:14530522 | lifeskim:mentions | umls-concept:C0035015 | lld:lifeskim |
| pubmed-article:14530522 | lifeskim:mentions | umls-concept:C0205082 | lld:lifeskim |
| pubmed-article:14530522 | lifeskim:mentions | umls-concept:C1882923 | lld:lifeskim |
| pubmed-article:14530522 | lifeskim:mentions | umls-concept:C1548437 | lld:lifeskim |
| pubmed-article:14530522 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:14530522 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:14530522 | pubmed:dateCreated | 2003-10-7 | lld:pubmed |
| pubmed-article:14530522 | pubmed:abstractText | Small animal models with the capacity to support engraftment of a functional human immune system are needed to facilitate studies of human alloimmunity. In the present investigation, non-obese diabetic (NOD) severe combined immunodeficient (scid) beta2-microglobulin-null (B2mnull) mice engrafted with human peripheral blood lymphocytes (hu-PBL-NOD-scid B2mnull mice) were used as in vivo models for studying human skin allograft rejection. Hu-PBL-NOD-scid B2mnull mice were established by injection of human spleen cells or PBLs and transplanted with full-thickness allogeneic human skin. Human cell engraftment was enhanced by injection of anti-mouse CD122 antibody. The respective contributions of human CD4+ and CD8+ cells in allograft rejection were determined using depleting antibodies. Human skin grafts on unmanipulated NOD-scid B2mnull mice uniformly survived but on chimeric hu-PBL-NOD-scid B2mnull mice exhibited severe immune-mediated injury that often progressed to complete rejection. The alloaggressive hu-PBLs did not require prior in vitro sensitization to elicit targeted effector cell activity. Extensive mononuclear cell infiltration directed towards human-origin endothelium was associated with thrombosis and fibrin necrosis. No evidence of graft-versus-host disease was detected. Either CD4+ or CD8+ T cells may mediate injury and alloimmune rejection of human skin grafts on hu-PBL-NOD-scid B2mnull mice. It is proposed that Hu-PBL-NOD-scid B2mnull mice engrafted with human skin will provide a useful model for analysis of interventions designed to modulate human allograft rejection. | lld:pubmed |
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| pubmed-article:14530522 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14530522 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14530522 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14530522 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14530522 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14530522 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:14530522 | pubmed:issn | 1535-3702 | lld:pubmed |
| pubmed-article:14530522 | pubmed:author | pubmed-author:TurgeonNicole... | lld:pubmed |
| pubmed-article:14530522 | pubmed:author | pubmed-author:RossiniAldo... | lld:pubmed |
| pubmed-article:14530522 | pubmed:author | pubmed-author:LyonsBonnie... | lld:pubmed |
| pubmed-article:14530522 | pubmed:author | pubmed-author:ShultzLeonard... | lld:pubmed |
| pubmed-article:14530522 | pubmed:author | pubmed-author:GreinerDale... | lld:pubmed |
| pubmed-article:14530522 | pubmed:author | pubmed-author:MordesJohn... | lld:pubmed |
| pubmed-article:14530522 | pubmed:author | pubmed-author:BanuelosScott... | lld:pubmed |
| pubmed-article:14530522 | pubmed:author | pubmed-author:AppelMichael... | lld:pubmed |
| pubmed-article:14530522 | pubmed:author | pubmed-author:IwakoshiNealN | lld:pubmed |
| pubmed-article:14530522 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14530522 | pubmed:volume | 228 | lld:pubmed |
| pubmed-article:14530522 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14530522 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14530522 | pubmed:pagination | 1096-104 | lld:pubmed |
| pubmed-article:14530522 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:14530522 | pubmed:meshHeading | pubmed-meshheading:14530522... | lld:pubmed |
| pubmed-article:14530522 | pubmed:meshHeading | pubmed-meshheading:14530522... | lld:pubmed |
| pubmed-article:14530522 | pubmed:meshHeading | pubmed-meshheading:14530522... | lld:pubmed |
| pubmed-article:14530522 | pubmed:meshHeading | pubmed-meshheading:14530522... | lld:pubmed |
| pubmed-article:14530522 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14530522 | pubmed:articleTitle | Alloimmune injury and rejection of human skin grafts on human peripheral blood lymphocyte-reconstituted non-obese diabetic severe combined immunodeficient beta2-microglobulin-null mice. | lld:pubmed |
| pubmed-article:14530522 | pubmed:affiliation | University of Massachusetts Medical School, Worcester, Massachussetts 01605, USA. | lld:pubmed |
| pubmed-article:14530522 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14530522 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14530522 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14530522 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14530522 | lld:pubmed |
