| pubmed-article:14528303 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14528303 | lifeskim:mentions | umls-concept:C0023516 | lld:lifeskim |
| pubmed-article:14528303 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:14528303 | lifeskim:mentions | umls-concept:C1155065 | lld:lifeskim |
| pubmed-article:14528303 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:14528303 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:14528303 | lifeskim:mentions | umls-concept:C0449864 | lld:lifeskim |
| pubmed-article:14528303 | lifeskim:mentions | umls-concept:C0441994 | lld:lifeskim |
| pubmed-article:14528303 | lifeskim:mentions | umls-concept:C0242210 | lld:lifeskim |
| pubmed-article:14528303 | lifeskim:mentions | umls-concept:C0391551 | lld:lifeskim |
| pubmed-article:14528303 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:14528303 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:14528303 | pubmed:dateCreated | 2003-10-30 | lld:pubmed |
| pubmed-article:14528303 | pubmed:abstractText | Leukocyte functional antigen 1 (LFA-1), with intercellular adhesion molecule ligands, mediates T cell adhesion, but the signaling pathways and functional effects imparted by LFA-1 are unclear. Here, intracellular phosphoprotein staining with 13-dimensional flow cytometry showed that LFA-1 activation induced phosphorylation of the beta(2) integrin chain and release of Jun-activating binding protein 1 (JAB-1), and mediated signaling of kinase Erk1/2 through cytohesin-1. Dominant negatives of both JAB-1 and cytohesin-1 inhibited interleukin 2 production and impaired T helper type 1 differentiation. LFA-1 stimulation lowered the threshold of T cell activation. Thus, LFA-1 signaling contributes to T cell activation and effects T cell differentiation. | lld:pubmed |
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| pubmed-article:14528303 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14528303 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14528303 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14528303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14528303 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14528303 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14528303 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:14528303 | pubmed:author | pubmed-author:PerezOmar DOD | lld:pubmed |
| pubmed-article:14528303 | pubmed:author | pubmed-author:NolanGarry... | lld:pubmed |
| pubmed-article:14528303 | pubmed:author | pubmed-author:MitchellDenni... | lld:pubmed |
| pubmed-article:14528303 | pubmed:author | pubmed-author:KinoshitaShig... | lld:pubmed |
| pubmed-article:14528303 | pubmed:author | pubmed-author:McBrideJacque... | lld:pubmed |
| pubmed-article:14528303 | pubmed:author | pubmed-author:JagerGina CGC | lld:pubmed |
| pubmed-article:14528303 | pubmed:author | pubmed-author:SouthSharonS | lld:pubmed |
| pubmed-article:14528303 | pubmed:author | pubmed-author:MurrielChrisC | lld:pubmed |
| pubmed-article:14528303 | pubmed:author | pubmed-author:HerzenbergLee... | lld:pubmed |
| pubmed-article:14528303 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14528303 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:14528303 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14528303 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14528303 | pubmed:pagination | 1083-92 | lld:pubmed |
| pubmed-article:14528303 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:14528303 | pubmed:meshHeading | pubmed-meshheading:14528303... | lld:pubmed |
| pubmed-article:14528303 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14528303 | pubmed:articleTitle | Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1. | lld:pubmed |
| pubmed-article:14528303 | pubmed:affiliation | Department of Microbiology and Immunology, and The Baxter Laboratory of Genetic Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA. | lld:pubmed |
| pubmed-article:14528303 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14528303 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14528303 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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