| pubmed-article:14520699 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14520699 | lifeskim:mentions | umls-concept:C0086427 | lld:lifeskim |
| pubmed-article:14520699 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:14520699 | lifeskim:mentions | umls-concept:C0288472 | lld:lifeskim |
| pubmed-article:14520699 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:14520699 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:14520699 | lifeskim:mentions | umls-concept:C0249197 | lld:lifeskim |
| pubmed-article:14520699 | lifeskim:mentions | umls-concept:C1332733 | lld:lifeskim |
| pubmed-article:14520699 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:14520699 | lifeskim:mentions | umls-concept:C0039371 | lld:lifeskim |
| pubmed-article:14520699 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:14520699 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:14520699 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:14520699 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:14520699 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:14520699 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:14520699 | pubmed:dateCreated | 2003-10-1 | lld:pubmed |
| pubmed-article:14520699 | pubmed:abstractText | We investigated the possible involvement of HTLV-1 Tax in the transcriptional activation of p21/Waf1/Cip1 (hereafter p21), a potent inhibitor of cyclin-dependent kinases and cell growth. Tax transfection resulted in enhanced expression of p21 protein in T and fibroblastoid cells. Similarly, Tax-expressing cells have higher amounts of endogenous p21 protein and RNA. However, neither Tax-negative, HTLV-1 transformed cells or HTLV-1-negative T cell lines had detectable levels of p21 protein and RNA. Cotransfection of Tax strongly activated the p21 promoter. CREB/ATF defective Tax mutant (M47) activated the p21 promoter significantly less efficiently. Tax activated wild type (wt) p21 promoter in p53-negative Jurkat and p53-positive A301cells, irrespective of endogenous p53 status, and activated a mutant p21 promoter containing a p53 responsive element (p53RE) deletion as strongly as wt promoter. Of importance, cdk2 activity was almost completely abolished in Tax-induced p21-expressing MT-2 cells, suggesting that Tax-induced p21 predominantly affects the activity of cdk2, a late G1 and S phase kinase. Taken together, these findings suggest that HTLV-1 Tax activates p21/Waf1/Cip1, a cell growth inhibitor, in a p53-independent mechanism through CREB/ATF-related transcription factors, and inhibits cdk2. Tax induction of p21 may balance the T-cell proliferation function of Tax and may contribute to the long clinical latency of HTLV-1 infection and the delayed development of adult T-cell leukemia. | lld:pubmed |
| pubmed-article:14520699 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14520699 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14520699 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14520699 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14520699 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14520699 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14520699 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:14520699 | pubmed:author | pubmed-author:BirxDeborah... | lld:pubmed |
| pubmed-article:14520699 | pubmed:author | pubmed-author:WangXiao-FanX... | lld:pubmed |
| pubmed-article:14520699 | pubmed:author | pubmed-author:RobbMerlin... | lld:pubmed |
| pubmed-article:14520699 | pubmed:author | pubmed-author:ChowdhuryIqba... | lld:pubmed |
| pubmed-article:14520699 | pubmed:author | pubmed-author:KimJerome HJH | lld:pubmed |
| pubmed-article:14520699 | pubmed:author | pubmed-author:FarhadiArashA | lld:pubmed |
| pubmed-article:14520699 | pubmed:copyrightInfo | Copyright 2003 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:14520699 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14520699 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:14520699 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:14520699 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14520699 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14520699 | pubmed:pagination | 603-11 | lld:pubmed |
| pubmed-article:14520699 | pubmed:dateRevised | 2010-2-4 | lld:pubmed |
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| pubmed-article:14520699 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14520699 | pubmed:articleTitle | Human T-cell leukemia virus type 1 Tax activates cyclin-dependent kinase inhibitor p21/Waf1/Cip1 expression through a p53-independent mechanism: Inhibition of cdk2. | lld:pubmed |
| pubmed-article:14520699 | pubmed:affiliation | Department of Vaccine Development and Research, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, MD, USA. chowdhui@mail.nih.gov | lld:pubmed |
| pubmed-article:14520699 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14520699 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14520699 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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