| pubmed-article:14514656 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14514656 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:14514656 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:14514656 | lifeskim:mentions | umls-concept:C0012155 | lld:lifeskim |
| pubmed-article:14514656 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:14514656 | lifeskim:mentions | umls-concept:C0040845 | lld:lifeskim |
| pubmed-article:14514656 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:14514656 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:14514656 | lifeskim:mentions | umls-concept:C0439232 | lld:lifeskim |
| pubmed-article:14514656 | lifeskim:mentions | umls-concept:C1515075 | lld:lifeskim |
| pubmed-article:14514656 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:14514656 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:14514656 | pubmed:dateCreated | 2003-12-24 | lld:pubmed |
| pubmed-article:14514656 | pubmed:abstractText | Chemopreventive activity by retinoic acid (RA) has been demonstrated previously in rat colon. The spontaneous tumourigenesis in the Min/+ mouse, which harbours a germline mutation in the tumour suppressor gene adenomatous polyposis coli (Apc), is characterized by inactivation of Apc, nuclear accumulation of beta-catenin and the enhanced expression of specific genes activated by T cell factor (TCF)/beta-catenin signalling. Recently it was reported that beta-catenin interacts with retinoic acid receptor in a retinoid-dependent manner, reducing beta-catenin/TCF regulated transcription. Our hypothesis was therefore that dietary supplementation with all-trans RA may inhibit the Apc-driven tumourigenesis in Min/+ mice. Surprisingly, in two different experiments the results showed that dietary RA significantly stimulated both the formation and growth of small intestinal tumours. In the first experiment Min/+ mice were exposed to 50 mg 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine/kg bodyweight at day 3-6 after birth and then treated with 50 mg/kg dietary RA in 1-3 weeks from the age of 2 weeks. In the second experiment the mice were not treated with carcinogen, and the diet was supplemented with 5 or 10 mg/kg RA from the age of 4 weeks until termination of the experiment at 11 weeks. Immunohistochemical studies revealed no differences in beta-catenin, cyclin D1 or proliferating cell nuclear antigen staining following RA treatment. There was no intestinal toxicity in mice fed 10 mg/kg RA, indicating that the increased tumourigenesis in Min/+ mice is a specific effect of all-trans RA. | lld:pubmed |
| pubmed-article:14514656 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14514656 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14514656 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14514656 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14514656 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14514656 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14514656 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14514656 | pubmed:issn | 0143-3334 | lld:pubmed |
| pubmed-article:14514656 | pubmed:author | pubmed-author:PaulsenJan... | lld:pubmed |
| pubmed-article:14514656 | pubmed:author | pubmed-author:AlexanderJanJ | lld:pubmed |
| pubmed-article:14514656 | pubmed:author | pubmed-author:MøllersenLind... | lld:pubmed |
| pubmed-article:14514656 | pubmed:author | pubmed-author:OlstørnHege... | lld:pubmed |
| pubmed-article:14514656 | pubmed:author | pubmed-author:KnutsenHelle... | lld:pubmed |
| pubmed-article:14514656 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14514656 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:14514656 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14514656 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14514656 | pubmed:pagination | 149-53 | lld:pubmed |
| pubmed-article:14514656 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:14514656 | pubmed:meshHeading | pubmed-meshheading:14514656... | lld:pubmed |
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| pubmed-article:14514656 | pubmed:meshHeading | pubmed-meshheading:14514656... | lld:pubmed |
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| pubmed-article:14514656 | pubmed:meshHeading | pubmed-meshheading:14514656... | lld:pubmed |
| pubmed-article:14514656 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14514656 | pubmed:articleTitle | Dietary retinoic acid supplementation stimulates intestinal tumour formation and growth in multiple intestinal neoplasia (Min)/+ mice. | lld:pubmed |
| pubmed-article:14514656 | pubmed:affiliation | Department of Food Toxicology, Norwegian Institute of Public Health, Oslo, Norway. | lld:pubmed |
| pubmed-article:14514656 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14514656 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:11789 | entrezgene:pubmed | pubmed-article:14514656 | lld:entrezgene |
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