| pubmed-article:14510951 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14510951 | lifeskim:mentions | umls-concept:C0376387 | lld:lifeskim |
| pubmed-article:14510951 | lifeskim:mentions | umls-concept:C0235032 | lld:lifeskim |
| pubmed-article:14510951 | lifeskim:mentions | umls-concept:C0054450 | lld:lifeskim |
| pubmed-article:14510951 | lifeskim:mentions | umls-concept:C1504389 | lld:lifeskim |
| pubmed-article:14510951 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:14510951 | lifeskim:mentions | umls-concept:C1515895 | lld:lifeskim |
| pubmed-article:14510951 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:14510951 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:14510951 | pubmed:dateCreated | 2003-9-26 | lld:pubmed |
| pubmed-article:14510951 | pubmed:abstractText | Calcineurin inhibitor-induced central nervous system toxicities are uncommon and often resolve after discontinuation of the offending drug. The long-term outcome of these patients is, however, unknown. Resolution of symptoms occurred in 70% of 30 allografted recipients who developed calcineurin inhibitor-induced neurotoxicity. When patients were rechallenged with the same or a different calcineurin inhibitor, symptoms recurred in 41%, leading to permanent discontinuation of the drug. De novo or progressive acute graft-versus-host disease (GVHD) was observed in 54% of patients at a median of 7 d (range 1-70 d) after initial onset of neurotoxicity. The prognosis was grim, with 24 (80%) of these patients dying a median 33 d after the onset of neurotoxicity (range 2-594 d). GVHD and/or infection occurred in 54% and were the most common primary causes of death. We conclude that calcineurin inhibitor-induced neurotoxicity is frequently reversible but associated with a poor prognosis. | lld:pubmed |
| pubmed-article:14510951 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14510951 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14510951 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14510951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14510951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14510951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14510951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14510951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14510951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14510951 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14510951 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:14510951 | pubmed:issn | 0007-1048 | lld:pubmed |
| pubmed-article:14510951 | pubmed:author | pubmed-author:BrownRandyR | lld:pubmed |
| pubmed-article:14510951 | pubmed:author | pubmed-author:KhouryHannaH | lld:pubmed |
| pubmed-article:14510951 | pubmed:author | pubmed-author:DiPersioJohn... | lld:pubmed |
| pubmed-article:14510951 | pubmed:author | pubmed-author:GoodnoughLawr... | lld:pubmed |
| pubmed-article:14510951 | pubmed:author | pubmed-author:VijRaviR | lld:pubmed |
| pubmed-article:14510951 | pubmed:author | pubmed-author:BlumWilliamW | lld:pubmed |
| pubmed-article:14510951 | pubmed:author | pubmed-author:AdkinsDouglas... | lld:pubmed |
| pubmed-article:14510951 | pubmed:author | pubmed-author:ChohanRizwana... | lld:pubmed |
| pubmed-article:14510951 | pubmed:author | pubmed-author:TomassonMicha... | lld:pubmed |
| pubmed-article:14510951 | pubmed:author | pubmed-author:DevineStevenS | lld:pubmed |
| pubmed-article:14510951 | pubmed:author | pubmed-author:GraubertTimot... | lld:pubmed |
| pubmed-article:14510951 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14510951 | pubmed:volume | 123 | lld:pubmed |
| pubmed-article:14510951 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14510951 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14510951 | pubmed:pagination | 110-3 | lld:pubmed |
| pubmed-article:14510951 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:14510951 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14510951 | pubmed:articleTitle | Long-term outcomes of allogeneic stem cell transplant recipients after calcineurin inhibitor-induced neurotoxicity. | lld:pubmed |
| pubmed-article:14510951 | pubmed:affiliation | Washington University School of Medicine, Department of Medicine, Division of Oncology, Section of Leukaemia & Bone Marrow Transplantation, St Louis, MO 63110-1093, USA. | lld:pubmed |
| pubmed-article:14510951 | pubmed:publicationType | Journal Article | lld:pubmed |
