| pubmed-article:14509931 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14509931 | lifeskim:mentions | umls-concept:C0011854 | lld:lifeskim |
| pubmed-article:14509931 | lifeskim:mentions | umls-concept:C0030274 | lld:lifeskim |
| pubmed-article:14509931 | lifeskim:mentions | umls-concept:C0008328 | lld:lifeskim |
| pubmed-article:14509931 | lifeskim:mentions | umls-concept:C0678896 | lld:lifeskim |
| pubmed-article:14509931 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:14509931 | lifeskim:mentions | umls-concept:C0184959 | lld:lifeskim |
| pubmed-article:14509931 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:14509931 | pubmed:dateCreated | 2003-9-26 | lld:pubmed |
| pubmed-article:14509931 | pubmed:abstractText | To investigate the role of cholecystokinin (ChCK) in the pathogenesis of insulin-dependent diabetes mellitus (IDDM) and to search the ways of its treatment with good prospects we conducted a comparative study of the effects of chronic conjunctive instillations (c.i.)) and intracerebroventricular administrations (i.c.v.) of cholecystokinin octapeptide (ChCK-8) to intact and streptozotocin-induced IDDM rats. The state of alpha- and beta-cells in pancreatic islets was studied by immunocytochemical method with a subsequent quantitative analysis on an automatic image analysis system. Our investigation has shown that in healthy rats both i.c.v. and c.i. administrations of ChCK-8 induced a significant increase in glycemia due to stimulation of alpha-cells and depression of beta-cells. However effects of ChCK-8 on the synthesis and secretion of insulin prevailed at i.c.v. administrations, while ChCK-8 administrated by c.i. was more potent in stimulating alpha-cells. Both ways of ChCK-8 administrations to a IDDM rats caused a positive effect on those animals by inhibiting a destruction of beta-cells, stimulating their function, and decreasing the content of alpha-cells in pancreatic islets which lead to a significant increase in insulin and a decrease in glucose in blood. | lld:pubmed |
| pubmed-article:14509931 | pubmed:language | ukr | lld:pubmed |
| pubmed-article:14509931 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14509931 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14509931 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14509931 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14509931 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14509931 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14509931 | pubmed:author | pubmed-author:AbramovA VAV | lld:pubmed |
| pubmed-article:14509931 | pubmed:author | pubmed-author:KolesnykIu... | lld:pubmed |
| pubmed-article:14509931 | pubmed:author | pubmed-author:Orlovs'ky?M... | lld:pubmed |
| pubmed-article:14509931 | pubmed:author | pubmed-author:Zhulyns'ky?V... | lld:pubmed |
| pubmed-article:14509931 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:14509931 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14509931 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14509931 | pubmed:pagination | 72-9 | lld:pubmed |
| pubmed-article:14509931 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:14509931 | pubmed:meshHeading | pubmed-meshheading:14509931... | lld:pubmed |
| pubmed-article:14509931 | pubmed:meshHeading | pubmed-meshheading:14509931... | lld:pubmed |
| pubmed-article:14509931 | pubmed:meshHeading | pubmed-meshheading:14509931... | lld:pubmed |
| pubmed-article:14509931 | pubmed:meshHeading | pubmed-meshheading:14509931... | lld:pubmed |
| pubmed-article:14509931 | pubmed:meshHeading | pubmed-meshheading:14509931... | lld:pubmed |
| pubmed-article:14509931 | pubmed:meshHeading | pubmed-meshheading:14509931... | lld:pubmed |
| pubmed-article:14509931 | pubmed:meshHeading | pubmed-meshheading:14509931... | lld:pubmed |
| pubmed-article:14509931 | pubmed:meshHeading | pubmed-meshheading:14509931... | lld:pubmed |
| pubmed-article:14509931 | pubmed:meshHeading | pubmed-meshheading:14509931... | lld:pubmed |
| pubmed-article:14509931 | pubmed:meshHeading | pubmed-meshheading:14509931... | lld:pubmed |
| pubmed-article:14509931 | pubmed:meshHeading | pubmed-meshheading:14509931... | lld:pubmed |
| pubmed-article:14509931 | pubmed:meshHeading | pubmed-meshheading:14509931... | lld:pubmed |
| pubmed-article:14509931 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14509931 | pubmed:articleTitle | [Effect of conjunctive instillation of cholecystokinin 26-33 on pancreatic endocrine function in type 1 diabetes mellitus]. | lld:pubmed |
| pubmed-article:14509931 | pubmed:affiliation | Zhaporozhye State Medical University. | lld:pubmed |
| pubmed-article:14509931 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14509931 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:14509931 | pubmed:publicationType | English Abstract | lld:pubmed |
